Impairment of immunological synapse formation in adaptively tolerant T cells (Q35091278)

6 August 2017

title

Impairment of immunological synapse formation in adaptively tolerant T cells (English)

1 reference

6 August 2017

1 reference

Seeyoung Choi

1

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6 August 2017

Ronald H Schwartz

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

17 June 2011

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6 August 2017

published in

Journal of Immunology

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6 August 2017

volume

187

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6 August 2017

issue

2

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6 August 2017

page(s)

805-816

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Function of the nucleotide exchange activity of vav1 in T cell development and activation

6 August 2017

cites work

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Regulation of T-cell activation by the cytoskeleton

8 July 2018

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Recruitment of dynein to the Jurkat immunological synapse

8 July 2018

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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

8 July 2018

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Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

8 July 2018

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The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

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8 July 2018

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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

8 July 2018

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

8 July 2018

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Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1

8 July 2018

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The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4 T Cells

8 July 2018

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8 July 2018

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Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

8 July 2018

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

8 July 2018

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SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

8 July 2018

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All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton

8 July 2018

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8 July 2018

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In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

8 July 2018

1 reference

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The regulation of actin remodeling during T-cell-APC conjugate formation

8 July 2018

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

8 July 2018

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Transcriptional mechanisms underlying lymphocyte tolerance.

8 July 2018

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T cell receptor signaling precedes immunological synapse formation

8 July 2018

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Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

8 July 2018

1 reference

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

8 July 2018

1 reference

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Tec family kinases modulate thresholds for thymocyte development and selection

8 July 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

8 July 2018

1 reference

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Regulation of integrin function by T cell activation: points of convergence and divergence

8 July 2018

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The immunological synapse: a molecular machine controlling T cell activation

8 July 2018

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Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

8 July 2018

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8 July 2018

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Three-dimensional segregation of supramolecular activation clusters in T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Models of T cell anergy: is there a common molecular mechanism?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

27 September 2018

1 reference

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HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

The immunological synapse balances T cell receptor signaling and degradation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Coupling of the TCR to integrin activation by Slap-130/Fyb.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

CTLA-4 engagement acts as a brake on CD4 T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

8 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131438

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

8 December 2018

1 reference

12 December 2020

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness

1 reference

12 December 2020

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

1 reference

12 December 2020

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1 reference

12 December 2020

T lymphocyte costimulation mediated by reorganization of membrane microdomains

1 reference

12 December 2020

Orally tolerized T cells can form conjugates with APCs but are defective in immunological synapse formation

1 reference

12 December 2020

Adaptive tolerance and clonal anergy are distinct biochemical states

1 reference

12 December 2020

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

1 reference

12 December 2020

Adaptive tolerance of CD4 T cells in vivo: multiple thresholds in response to a constant level of antigen presentation

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1003314

1 reference

6 August 2017

1 reference

6 August 2017

1 reference