Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS) (Q35080064)

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3 February 2020

title

Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS) (English)

1 reference

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3 February 2020

1 reference

4

1 reference

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3 February 2020

Joséphine Zangari

6

1 reference

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3 February 2020

Robert Ballotti

14

1 reference

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3 February 2020

Corine Bertolotto

15

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Brigitte Bressac-de Paillerets

3 February 2020

9

object named as

Brigitte Bressac-de Paillerets

1 reference

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3 February 2020

author name string

Mickaël Ohanna

1

1 reference

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3 February 2020

Sandy Giuliano

2

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3 February 2020

Caroline Bonet

3

1 reference

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3 February 2020

Véronique Hofman

5

1 reference

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Karine Bille

7

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3 February 2020

Paul Hofman

10

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3 February 2020

Stéphane Rocchi

11

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Jean-François Peyron

12

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Jean-Philippe Lacour

13

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Caroline Robert

8

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publication date

6 June 2011

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3 February 2020

1 reference

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3 February 2020

volume

25

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3 February 2020

issue

12

1 reference

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3 February 2020

page(s)

1245-1261

1 reference

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Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny.

3 February 2020

cites work

1 reference

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Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma.

8 July 2018

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Interferon-γ links ultraviolet radiation to melanomagenesis in mice

8 July 2018

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Advances in melanoma senescence and potential clinical application.

8 July 2018

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An integrated approach to uncover drivers of cancer.

8 July 2018

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Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

8 July 2018

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Tumors induce complex DNA damage in distant proliferative tissues in vivo

8 July 2018

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Conditional ablation of Ikkb inhibits melanoma tumor development in mice

8 July 2018

1 reference

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Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent

8 July 2018

1 reference

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The nuclear factor NF-kappaB pathway in inflammation

8 July 2018

1 reference

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Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas.

8 July 2018

1 reference

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Cross talk between stimulated NF-kappaB and the tumor suppressor p53.

8 July 2018

1 reference

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An oncogenic role for ETV1 in melanoma

8 July 2018

1 reference

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Stepping up melanocytes to the challenge of UV exposure

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

The senescence-associated secretory phenotype: the dark side of tumor suppression

8 July 2018

1 reference

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Fifteen-year quest for microphthalmia-associated transcription factor target genes

8 July 2018

1 reference

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A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Senescence-messaging secretome: SMS-ing cellular stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion.

8 July 2018

1 reference

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Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Living on a break: cellular senescence as a DNA-damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Chemokine signaling via the CXCR2 receptor reinforces senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

DNA repair pathways as targets for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Temozolomide induces senescence but not apoptosis in human melanoma cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Apoptosis and melanoma chemoresistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

PARP-1 modifies the effectiveness of p53-mediated DNA damage response.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Cell cycle checkpoints: preventing an identity crisis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Cell cycle control and cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

The ATM protein is required for sustained activation of NF-kappaB following DNA damage

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127427

Transient expression of human telomerase extends the life span of normal human fibroblasts

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21646373

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21646373

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21646373

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.625811

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21646373 AND SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21646373 AND SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

21646373

1 reference