An evolutionary and structural perspective on T cell antigen receptor function (Q35076666)

6 August 2017

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title

An evolutionary and structural perspective on T cell antigen receptor function (English)

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6 August 2017

1

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6 August 2017

publication date

1 February 2003

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6 August 2017

published in

Immunological Reviews

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6 August 2017

volume

191

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6 August 2017

page(s)

7-27

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Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells

6 August 2017

cites work

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CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.

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Unexpected signals in a system subject to kinetic proofreading

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Structure of a human gammadelta T-cell antigen receptor

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The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules.

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Directed evolution of proteins by exon shuffling

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Evidence for a stepwise evolution of the CD3 family

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The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

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Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

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Quantitative aspects of signal transduction by the receptor with high affinity for IgE.

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Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

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Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection

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Specific requirement for CD3epsilon in T cell development.

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Interaction between the unphosphorylated receptor with high affinity for IgE and Lyn kinase

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Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

21 January 2018

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In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

21 January 2018

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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

21 January 2018

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

21 January 2018

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B cells acquire antigen from target cells after synapse formation

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Uncertainties - discrepancies in immunology

21 January 2018

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T-cell-receptor gene therapy

21 January 2018

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So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes

21 January 2018

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The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

21 January 2018

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The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

21 January 2018

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A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

21 January 2018

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Soluble peptide-MHC monomers cause activation of CD8 T cells through transfer of the peptide to T cell MHC molecules

21 January 2018

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Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules

21 January 2018

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Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

21 January 2018

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Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

21 January 2018

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Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo

21 January 2018

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Natural and engineered disorders of lymphocyte development

21 January 2018

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Autoreactivity by design: innate B and T lymphocytes

21 January 2018

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In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes

21 January 2018

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TCR specificity dictates CD94/NKG2A expression by human CTL.

21 January 2018

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A Role for Src in Signal Relay by the Platelet-derived Growth Factor α Receptor

21 January 2018

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Epidermal growth factor receptors: critical mediators of multiple receptor pathways

21 January 2018

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ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation

21 January 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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Dockers at the crossroads

21 January 2018

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Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus

21 January 2018

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Cloning of Japanese flounder Paralichthys olivaceus CD3 cDNA and gene, and analysis of its expression

21 January 2018

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Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12

21 January 2018

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T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation

21 January 2018

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

21 January 2018

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A piston model for transmembrane signaling of the aspartate receptor

21 January 2018

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Mechanism of glutamate receptor desensitization

21 January 2018

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Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

21 January 2018

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Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

21 January 2018

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T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase

21 January 2018

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Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

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A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

CTL activation is induced by cross-linking of TCR/MHC-peptide-CD8/p56lck adducts in rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

21 January 2018

1 reference

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Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

21 January 2018

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CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

21 January 2018

1 reference

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Two faces are better than one

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

Requirement for a Negative Charge at Threonine 60 of the FcRγ for Complete Activation of Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

21 January 2018

The semiotics of charge

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

Kinetic proofreading in T-cell receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

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7 January 2021

Distinct structure and signaling potential of the gamma delta TCR complex

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7 January 2021

CD3 delta establishes a functional link between the T cell receptor and CD8

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development.

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Rapid turnover of the CD3 zeta chain independent of the TCR-CD3 complex in normal T cells

1 reference

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7 January 2021

Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation

1 reference

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7 January 2021

Membrane-bound ezrin is involved in B-cell receptor-mediated signaling: potential role of an ITAM-like ezrin motif

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon.

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

alpha beta T cell receptor ligand-specific oligomerization revisited

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

1 reference

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7 January 2021

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

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7 January 2021

Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

1 reference

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7 January 2021

Erythropoietin receptor activation by a ligand-induced conformation change

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Receptor modulators of B-cell receptor signalling--CD19/CD22.

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7 January 2021

Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Controlling Signal Transduction with Synthetic Ligands

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

High-efficiency expression and solubilization of functional T cell antigen receptor heterodimers

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

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7 January 2021

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

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7 January 2021

The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

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7 January 2021

Interplays between mouse mammary tumor virus and the cellular and humoral immune response.

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7 January 2021

Lateral propagation of EGF signaling after local stimulation is dependent on receptor density.

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7 January 2021

Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Interactions of TCR tyrosine based activation motifs with tyrosine kinases.

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

An amphibian CD3 homologue of the mammalian CD3 γ and δ genes

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7 January 2021

Activation-induced ubiquitination of the T cell antigen receptor

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

Monomeric and oligomeric complexes of the B cell antigen receptor

1 reference

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7 January 2021

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

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7 January 2021

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

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7 January 2021

Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding

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https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

1 reference

https://api.crossref.org/works/10.1034/J.1600-065X.2003.00016.X

7 January 2021

10.1034/J.1600-065X.2003.00016.X

Identifiers

DOI

1 reference

6 August 2017

1 reference