Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities (Q35074531)

6 August 2017

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title

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities (English)

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6 August 2017

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Kevin D Niswender

1

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6 August 2017

Michael W Schwartz

series ordinal

2

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6 August 2017

publication date

1 January 2003

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Frontiers in Neuroendocrinology

6 August 2017

published in

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6 August 2017

volume

24

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6 August 2017

issue

1

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6 August 2017

page(s)

1-10

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Acute third ventricular administration of insulin decreases food intake in two paradigms

6 August 2017

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7 January 2021

Activation of downstream signals by the long form of the leptin receptor

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Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain

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7 January 2021

The catabolic action of insulin in the brain is mediated by melanocortins.

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7 January 2021

Identification of binding sites for an insulin-like growth factor (IGF-I) in the median eminence of the rat brain by quantitative autoradiography

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7 January 2021

Role of brain insulin receptor in control of body weight and reproduction

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7 January 2021

IRS-2 pathways integrate female reproduction and energy homeostasis

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7 January 2021

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

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7 January 2021

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

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7 January 2021

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

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7 January 2021

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

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7 January 2021

Modulation of insulin activities by leptin

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7 January 2021

Selective deletion of leptin receptor in neurons leads to obesity

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7 January 2021

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

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7 January 2021

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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7 January 2021

Molecular mechanisms involved in GLUT4 translocation in muscle during insulin and contraction stimulation

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7 January 2021

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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7 January 2021

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

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7 January 2021

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

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7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

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7 January 2021

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

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7 January 2021

Genetic analysis of insulin signaling in Drosophila

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7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

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7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

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7 January 2021

Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line.

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7 January 2021

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

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7 January 2021

Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats

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7 January 2021

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs

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7 January 2021

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

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7 January 2021

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

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7 January 2021

The role of depot fat in the hypothalamic control of food intake in the rat.

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7 January 2021

Clinical review 125: The insulin receptor and its cellular targets

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7 January 2021

Prevention of fat-induced insulin resistance by salicylate

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7 January 2021

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

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7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

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7 January 2021

Action of insulin on the 'permeability' of cells to free hexoses, as studied by its effect on the distribution of galactose

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7 January 2021

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

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7 January 2021

Localization of insulin receptor mRNA in rat brain by in situ hybridization

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7 January 2021

The continuing epidemics of obesity and diabetes in the United States

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7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

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7 January 2021

Intracellular signalling. Key enzyme in leptin-induced anorexia

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7 January 2021

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain

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7 January 2021

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

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7 January 2021

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

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7 January 2021

Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells

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7 January 2021

Insulin signaling pathways in time and space.

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7 January 2021

Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats

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7 January 2021

Central nervous system control of food intake

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7 January 2021

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Cellular mechanisms of insulin resistance

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Low plasma leptin levels contribute to diabetic hyperphagia in rats

1 reference

https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Effects of leptin on insulin sensitivity in normal rats.

1 reference

https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels.

1 reference

https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Insulin activates ATP-sensitive K channels in hypothalamic neurons of lean, but not obese rats

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Obesity and the regulation of energy balance

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

The role of neuropeptide Y in the antiobesity action of the obese gene product

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7 January 2021

Insulin responses and glucose levels in plasma and cerebrospinal fluid during fasting and refeeding in the rat.

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

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7 January 2021

Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance

1 reference

https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man

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7 January 2021

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse

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https://api.crossref.org/works/10.1016/S0091-3022(02)00105-X

7 January 2021

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

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7 January 2021

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

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7 January 2021

Positional cloning of the mouse obese gene and its human homologue

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7 January 2021

Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes

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7 January 2021

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

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7 January 2021

10.1016/S0091-3022(02)00105-X

Identifiers

DOI

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release_mmzckm55kzgthd7hdga5sodeha

6 August 2017

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https://api.fatcat.wiki/v0/release/mmzckm55kzgthd7hdga5sodeha

24 November 2022

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