Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. (Q35071690)

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English	Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.	scientific article

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24 February 2020

Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease (English)

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24 February 2020

Alzheimer's disease

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entorhinal cortex

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Donald A Wilson

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24 February 2020

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Wenjin Xu

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24 February 2020

Shane Fitzgerald

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24 February 2020

Ralph A Nixon

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24 February 2020

Efrat Levy

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12 December 2014

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24 February 2020

Experimental Neurology

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24 February 2020

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24 February 2020

82-91

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24 February 2020

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The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

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Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease

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The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus

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Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo

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Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

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β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

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In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.

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Generalized vs. stimulus-specific learned fear differentially modifies stimulus encoding in primary sensory cortex of awake rats

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Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

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Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model

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In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice

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Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer's disease

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Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model

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12 December 2020

based on heuristic

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C-terminal fragment of amyloid precursor protein induces astrocytosis

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12 December 2020

based on heuristic

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10.1016/J.EXPNEUROL.2014.12.008

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Europe PubMed Central

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24 February 2020

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Europe PubMed Central

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24 February 2020

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Europe PubMed Central

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24 February 2020

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