Molecular origin of Gerstmann-Sträussler-Scheinker syndrome: insight from computer simulation of an amyloidogenic prion peptide. (Q35070483)

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5 February 2020

title

Molecular origin of Gerstmann-Sträussler-Scheinker syndrome: insight from computer simulation of an amyloidogenic prion peptide (English)

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1

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5 February 2020

Jeremy C Smith

series ordinal

3

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author name string

Alfredo Di Nola

series ordinal

2

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language of work or name

English

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publication date

1 June 2011

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volume

100

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issue

12

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page(s)

3000-3007

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Mechanism of fiber assembly: treatment of Aβ peptide aggregation with a coarse-grained united-residue force field

5 February 2020

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Contrasting disease and nondisease protein aggregation by molecular simulation

8 July 2018

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8 July 2018

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Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations

8 July 2018

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Mapping protein collapse with single-molecule fluorescence and kinetic synchrotron radiation circular dichroism spectroscopy

8 July 2018

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Folding and aggregation kinetics of a beta-hairpin

8 July 2018

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Correlations among morphology, beta-sheet stability, and molecular structure in prion peptide aggregates

8 July 2018

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Infrared study of the stability and folding kinetics of a 15-residue beta-hairpin

8 July 2018

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NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126.

8 July 2018

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The role of the unfolded state in hairpin stability

8 July 2018

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Games played by rogue proteins in prion disorders and Alzheimer's disease

8 July 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

8 July 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

8 July 2018

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Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects

8 July 2018

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Computational studies on prion proteins: effect of Ala(117)-->Val mutation

8 July 2018

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Measuring the rate of intramolecular contact formation in polypeptides

8 July 2018

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Protein misfolding, evolution and disease

8 July 2018

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Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation

8 July 2018

1 reference

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Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

8 July 2018

1 reference

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Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases

8 July 2018

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An extended sampling of the configurational space of HPr from E. coli.

8 July 2018

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Essential dynamics of proteins

8 July 2018

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Proposed three-dimensional structure for the cellular prion protein

8 July 2018

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

8 July 2018

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Prion protein gene variation among primates

8 July 2018

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Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells

8 July 2018

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Molecular biology of prion diseases

8 July 2018

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The H187R mutation of the human prion protein induces conversion of recombinant prion protein to the PrP(Sc)-like form

8 July 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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Thermodynamic and kinetic characterization of a beta-hairpin peptide in solution: an extended phase space sampling by molecular dynamics simulations in explicit water.

27 September 2018

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Beta-hairpin conformation of fibrillogenic peptides: structure and alpha-beta transition mechanism revealed by molecular dynamics simulations

27 September 2018

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Making a network of hydrophobic clusters

27 September 2018

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Altered toxicity of the prion protein peptide PrP106-126 carrying the Ala(117)-->Val mutation

27 September 2018

1 reference

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

27 September 2018

1 reference

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Prion protein peptides induce alpha-helix to beta-sheet conformational transitions

27 September 2018

1 reference

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Polypeptide chain folding in the hydrophobic core of hamster scrapie prion: analysis by X-ray diffraction

27 September 2018

1 reference

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The oligomerization properties of prion protein are restricted to the H2H3 domain

25 October 2018

1 reference

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Direct Observation of Protein Folding, Aggregation, and a Prion-like Conformational Conversion

9 December 2018

1 reference

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Structural Properties and Dynamic Behavior of Nonfibrillar Oligomers Formed by PrP(106−126)

9 December 2018

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12 December 2020

The Organization and Assembly of a β-Sheet Formed by a Prion Peptide in Solution: An Isotope-Edited FTIR Study

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12 December 2020

Nanosecond folding dynamics of a three-stranded beta-sheet

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12 December 2020

Folding time predictions from all-atom replica exchange simulations

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12 December 2020

Pathways and intermediates of amyloid fibril formation

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12 December 2020

10.1016/J.BPJ.2011.04.053

Identifiers

DOI

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5 February 2020

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5 February 2020

PubMed publication ID

21689534

1 reference