Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner (Q35063727)

24324597

6 August 2017

title

Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner (English)

1 reference

6 August 2017

3

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10 June 2020

Christoph Lossin

6

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10 June 2020

Shinichi Hirose

8

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10 June 2020

author name string

Yuki Nakamura

1

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10 June 2020

Xiuyu Shi

2

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10 June 2020

Yasuo Mori

4

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10 June 2020

Ryuji Inoue

5

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10 June 2020

Tallie Z Baram

7

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language of work or name

English

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publication date

4 December 2013

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6 August 2017

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volume

8

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issue

12

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page(s)

e80376

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Creative Commons Attribution 3.0 Unported

10 June 2020

copyright license

start time

4 December 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Neuron‐restrictive silencer factor‐mediated hyperpolarization‐activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Towards an integrated view of HCN channel role in epilepsy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Epileptogenesis after prolonged febrile seizures: Mechanisms, biomarkers and therapeutic opportunities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

HCN channels in behavior and neurological disease: Too hyper or not active enough?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Sodium channel SCN1A and epilepsy: mutations and mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Augmented currents of an HCN2 variant in patients with febrile seizure syndromes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Increased seizure severity and seizure-related death in mice lacking HCN1 channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

The fast and slow ups and downs of HCN channel regulation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Hyperpolarization-activated cation channels: from genes to function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Upregulated H-current in hyperexcitable CA1 dendrites after febrile seizures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Interaction of the pacemaker channel HCN1 with filamin A.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

The multiple personalities of h-channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

From funny current to HCN channels: 20 years of excitation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Functional heteromerization of HCN1 and HCN2 pacemaker channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

A family of hyperpolarization-activated mammalian cation channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

The hyperpolarization-activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens-alveus interneurones

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Hyperpolarization-activated currents in isolated superior colliculus-projecting neurons from rat visual cortex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.

8 July 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Sodium channel alpha1-subunit mutations in severe myoclonic epilepsy of infancy and infantile spasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Molecular mechanism of cAMP modulation of HCN pacemaker channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Hyperpolarization-activated currents regulate excitability in stellate cells of the mammalian ventral cochlear nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0080376

Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3851455

10.1371/JOURNAL.PONE.0080376

27 September 2018

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10 June 2020

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