The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death (Q35056257)

6 August 2017

title

The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death (English)

1 reference

6 August 2017

0 references

1 reference

2

Olga Greco

1 reference

6 August 2017

7

Gillian Tozer

1 reference

6 August 2017

Chryso Kanthou

1

1 reference

6 August 2017

Anna Stratford

3

1 reference

6 August 2017

Ian Cook

4

1 reference

6 August 2017

Richard Knight

5

1 reference

6 August 2017

Omar Benzakour

6

1 reference

6 August 2017

language of work or name

English

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publication date

1 October 2004

1 reference

The American Journal of Pathology

6 August 2017

published in

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6 August 2017

volume

165

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6 August 2017

issue

4

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6 August 2017

page(s)

1401-1411

1 reference

Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers

6 August 2017

cites work

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8 July 2018

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Mechanism of action of antitumor drugs that interact with microtubules and tubulin

8 July 2018

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8 July 2018

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The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses.

8 July 2018

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p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol

8 July 2018

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Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage

8 July 2018

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The biology of the combretastatins as tumour vascular targeting agents

8 July 2018

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Mitotic death: a mechanism of survival? A review

8 July 2018

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Docetaxel versus paclitaxel for antiangiogenesis

8 July 2018

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Paclitaxel triggers cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460.

8 July 2018

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Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Apoptotic cell death induced by baccatin III, a precursor of paclitaxel, may occur without G(2)/M arrest

8 July 2018

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Tumour vasculature as a target for cancer therapy.

8 July 2018

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Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity

8 July 2018

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Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase

8 July 2018

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Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The spindle assembly checkpoint

8 July 2018

1 reference

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Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

8 July 2018

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Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.

8 July 2018

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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.

8 July 2018

1 reference

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Universal control mechanism regulating onset of M-phase

8 July 2018

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Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity

8 July 2018

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Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.

25 October 2018

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Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.

25 October 2018

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25 October 2018

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Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

25 October 2018

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Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo

25 October 2018

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25 October 2018

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25 October 2018

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Vinca alkaloids: anti-vascular effects in a murine tumour

25 October 2018

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The tumour microcirculation as a target in cancer therapy: a clearer perspective

25 October 2018

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The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells

7 January 2021

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https://api.crossref.org/works/10.1016/S0002-9440(10)63398-6

Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism

7 January 2021

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Anti-vascular approaches to solid tumour therapy: evaluation of vinblastine and flavone acetic acid

7 January 2021

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Up-regulation of cdc2 protein during paclitaxel-induced apoptosis

7 January 2021

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cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF

7 January 2021

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https://api.crossref.org/works/10.1016/S0002-9440(10)63398-6

7 January 2021

Cell cycle and apoptosis

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https://api.crossref.org/works/10.1016/S0002-9440(10)63398-6

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15466404

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antiangiogenesis is produced by nontoxic doses of vinblastine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15466404

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15466404

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)63398-6

1 reference

6 August 2017

1 reference

6 August 2017

1 reference