The influence of sex on pharmacokinetics (Q35049301)

6 August 2017

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title

The influence of sex on pharmacokinetics (English)

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6 August 2017

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Janice B Schwartz

1

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6 August 2017

publication date

1 January 2003

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Clinical Pharmacokinetics

6 August 2017

published in

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6 August 2017

volume

42

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6 August 2017

issue

2

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6 August 2017

page(s)

107-121

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Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination

6 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.2165/00003088-200342020-00001

Influence of oral contraceptives on drug therapy

21 January 2018

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Crossref

https://api.crossref.org/works/10.2165/00003088-200342020-00001

Effect of age and gender on disposition of temazepam

21 January 2018

1 reference

12 December 2020

Effects of age and gender on pharmacokinetics of cefepime

1 reference

12 December 2020

In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil

1 reference

12 December 2020

Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism

1 reference

12 December 2020

Influence of sex and oral contraceptive steroids on paracetamol metabolism

1 reference

12 December 2020

Clinical experience with transdermal clonidine in African-American and Hispanic-American patients with hypertension: evaluation from a 12-week prospective, open-label clinical trial in community-based clinics

1 reference

12 December 2020

CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences

1 reference

12 December 2020

Gender affects doxorubicin pharmacokinetics in patients with normal liver biochemistry

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12 December 2020

Debrisoquine hydroxylation phenotyping in geriatric psychopharmacology

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12 December 2020

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12 December 2020

Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans

1 reference

12 December 2020

Pharmacokinetics of tirilazad and U-89678 in ischemic stroke patients receiving a loading regimen and maintenance regimen of 10 mg/kg/day of tirilazad

1 reference

12 December 2020

Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A.

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12 December 2020

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

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12 December 2020

Relative importance of dose, body surface area, sex, and age for 5-fluorouracil clearance

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12 December 2020

How important are gender differences in pharmacokinetics?

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12 December 2020

Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping

1 reference

12 December 2020

Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil

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12 December 2020

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12 December 2020

Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy*

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12 December 2020

Stereoselective binding of propranolol to human plasma, alpha 1-acid glycoprotein, and albumin

1 reference

12 December 2020

Development and pharmacology of fluvastatin.

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12 December 2020

Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects

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12 December 2020

Interactions Between Oral Contraceptives and Antifungals/Antibacterials

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12 December 2020

Clinical pharmacokinetics of alprazolam. Therapeutic implications

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12 December 2020

Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates

1 reference

12 December 2020

Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes

1 reference

12 December 2020

Population pharmacokinetics of continuous infusion ceftazidime

1 reference

12 December 2020

Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts

1 reference

12 December 2020

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities

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12 December 2020

Sex differences in pharmacokinetics of oral propranolol in healthy Chinese volunteers

1 reference

12 December 2020

Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Tomudex International Study Group.

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12 December 2020

Effect of hepatic dysfunction on oral cyclosporin pharmacokinetics in marrow transplant patients

1 reference

12 December 2020

Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer

1 reference

12 December 2020

Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population

1 reference

12 December 2020

Clinical pharmacokinetics of mirtazapine

1 reference

12 December 2020

Effect of normal aging on the activity of human hepatic cytochrome P450IIE1

1 reference

12 December 2020

The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis

1 reference

12 December 2020

Erythrocyte catechol-O-methyltransferase activity in a Swedish population

1 reference

12 December 2020

Diet, body size, and plasma lipids-lipoproteins in young adults: differences by race and sex. The Coronary Artery Risk Development in Young Adults (CARDIA) study.

1 reference

12 December 2020

Effects of age and sex on copper absorption, biological half-life, and status in humans

1 reference

12 December 2020

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism

1 reference

12 December 2020

Clinical pharmacokinetics of ropinirole

1 reference

12 December 2020

Plasma protein binding of basic drugs. II. Importance of alpha 1-acid glycoprotein for interindividual variation

1 reference

12 December 2020

Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine

1 reference

12 December 2020

Cerivastatin for hypercholesterolemia

1 reference

12 December 2020

Clinical pharmacokinetics of fluvastatin

1 reference

12 December 2020

Influence of sex and age on fluorouracil clearance

1 reference

12 December 2020

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole

1 reference

12 December 2020

Estimates of animal and plant protein intake in US adults: results from the Third National Health and Nutrition Examination Survey, 1988-1991

1 reference

12 December 2020

Application of a three-compartment model to a study of the effects of sex, alcohol dose and concentration, exercise and food consumption on the pharmacokinetics of ethanol in healthy volunteers

1 reference

12 December 2020

Clinical efficacy and safety of cerivastatin: summary of pivotal phase IIb/III studies

1 reference

12 December 2020

Effect of age, gender, and obesity on midazolam kinetics.

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12 December 2020

Oral contraceptive drug interactions: important considerations

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12 December 2020

Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage

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12 December 2020

Oxazepam kinetics: effects of age and sex.

1 reference

12 December 2020

Imipramine and desipramine disposition in the elderly

1 reference

12 December 2020

Pharmacokinetics, pharmacodynamics, and safety of inhaled cyclosporin A (ADI628) after single and repeated administration in healthy male and female subjects and asthmatic patients

1 reference

12 December 2020

Influence of menstrual cycle and gender on alprazolam pharmacokinetics

1 reference

12 December 2020

Effect of age and gender on the activity of human hepatic CYP3A

1 reference

12 December 2020

Diazepam Kinetics in Relation to Age and Sex

1 reference

12 December 2020

Gender and treatment outcome in childhood lymphoblastic leukaemia: report from the MRC UKALL trials

1 reference

12 December 2020

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12 December 2020

Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers.

1 reference

12 December 2020

Verapamil disposition kinetics in chronic atrial fibrillation

1 reference

12 December 2020

Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells.

1 reference

12 December 2020

Sex differences in fluorouracil-induced stomatitis

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12 December 2020

Molecular basis of ethnic differences in drug disposition and response

1 reference

12 December 2020

Metabolism of cytochrome P4503A substrates in vivo administered by the same route: lack of correlation between alfentanil clearance and erythromycin breath test.

1 reference

12 December 2020

Effect of age and sex on glomerular filtration rate measured by 51Cr-EDTA

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12 December 2020

Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity

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12 December 2020

Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute

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12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

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12 December 2020

Pharmacokinetic Changes During Pregnancy and Their Clinical Relevance

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12 December 2020

Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics

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12 December 2020

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

1 reference

12 December 2020

Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

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12 December 2020

Gender differences in drug metabolism regulated by growth hormone

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12 December 2020

Disposition and first-pass metabolism of ethanol in humans: is it gastric or hepatic and does it depend on gender?

1 reference

12 December 2020

Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics

1 reference

12 December 2020

Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype

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12 December 2020

Age and gender influence the stereoselective pharmacokinetics of propranolol

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12 December 2020

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms

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12 December 2020

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

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12 December 2020

Pharmacokinetic analysis of bioequivalence trials: implications for sex-related issues in clinical pharmacology and biopharmaceutics

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12 December 2020

Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal

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12 December 2020

Pharmacokinetic Drug Interactions with Oral Contraceptives

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12 December 2020

Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics.

1 reference

12 December 2020

Estimating the Dosage of Ribavirin Aerosol According to Age and Other Variables

1 reference

12 December 2020

Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population

1 reference

12 December 2020

Gender differences in chronic disease risk behaviors through the transition out of high school

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12 December 2020

Effect of age and sex on the plasma binding of acidic and basic drugs

1 reference

12 December 2020

Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics

1 reference

12 December 2020

Prediction of creatinine clearance from serum creatinine

1 reference

12 December 2020

Digoxin population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens

1 reference

12 December 2020

Cerivastatin in primary hyperlipidemia: a multicenter analysis of efficacy and safety

1 reference

12 December 2020

Effect of age and gender on tirilazad pharmacokinetics in humans

1 reference

12 December 2020

Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients

1 reference

12 December 2020

Verapamil protein binding in patients and in normal subjects

1 reference

12 December 2020

Gender differences in pharmacokinetics and pharmacodynamics

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12 December 2020

Identification of functionally variant MDR1 alleles among European Americans and African Americans

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12 December 2020

Absorption and disposition of ibuprofen in the elderly

1 reference

12 December 2020

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

1 reference

12 December 2020

Disposition of alprazolam in human volunteers. Differences between genders

1 reference

12 December 2020

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1 reference

12 December 2020

Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity

1 reference

12 December 2020

Route of administration and sex differences in the pharmacokinetics of aspirin, administered as its lysine salt

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12 December 2020

The effect of hormone replacement therapy on CYP3A activity

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12 December 2020

Race and sex influence clearance of nifedipine: results of a population study

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12 December 2020

Sex differences in biological factors putatively related to depression

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12 December 2020

Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability

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12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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12 December 2020

The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites

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12 December 2020

Diazepam disposition determinants.

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12 December 2020

Interethnic difference in thiopurine methyltransferase activity

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12 December 2020

Biologic determinants of propranolol disposition: results from 1308 patients in the Beta-Blocker Heart Attack Trial

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12 December 2020

Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies

1 reference

12 December 2020

Efficacy and safety of cerivastatin 0.8 mg in patients with hypercholesterolaemia: the pivotal placebo-controlled clinical trial. Cerivastatin Study Group

1 reference

12 December 2020

Acetaminophen kinetics in the elderly

1 reference

12 December 2020

Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs

1 reference

12 December 2020

Erythrocyte COMT-activity in patients with affective disorders

1 reference

12 December 2020

Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans

1 reference

12 December 2020

Gender effects in pharmacokinetics and pharmacodynamics

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12 December 2020

Human liver catechol-O-methyltransferase pharmacogenetics

1 reference

12 December 2020

Estrogens and the kidney

1 reference

12 December 2020

Metabolic effects and pharmacokinetics of a growth hormone pulse in healthy adults: relation to age, sex, and body composition

1 reference

12 December 2020

The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate

1 reference

12 December 2020

Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay

1 reference

12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

12 December 2020

Underrepresentation of women in clinical drug trials

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12 December 2020

Gender differences in human pharmacokinetics and pharmacodynamics

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12 December 2020

Clomipramine metabolism. Model-based analysis of variability factors from drug monitoring data

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12 December 2020

Gender differences in labetalol kinetics: importance of determining stereoisomer kinetics for racemic drugs

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12 December 2020

Olanzapine. Pharmacokinetic and pharmacodynamic profile.

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12 December 2020

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

1 reference

12 December 2020

Clinical pharmacokinetics of cerivastatin

1 reference

12 December 2020

1 reference

12 December 2020

The influence of age and gender on the stereoselective metabolism and pharmacokinetics of mephobarbital in humans

1 reference

12 December 2020

Alpha‐1‐Acid Glycoprotein Concentration and the Protein Binding of Disopyramide in Healthy Subjects

1 reference

12 December 2020

Vancomycin pharmacokinetics in a patient population: effect of age, gender, and body weight.

1 reference

12 December 2020

Transdermal delivery of narcotic analgesics: pH, anatomical, and subject influences on cutaneous permeability of fentanyl and sufentanil

1 reference

12 December 2020

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin

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12 December 2020

The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids

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12 December 2020

The effects of age and gender on the pharmacokinetics of irbesartan

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12 December 2020

Management of thrombosis in women with antiphospholipid syndrome

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12 December 2020

10.2165/00003088-200342020-00001

Identifiers

DOI

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Dimensions Publication ID

6 August 2017

1026963827

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