Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance (Q35043403)

6 August 2017

title

Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance (English)

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6 August 2017

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Fortunata Carbone

9

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John P Chamberland

object named as

John P Chamberland

Christos Socrates Mantzoros

4

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object named as

Christos S Mantzoros

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Benjamin E Schneider

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Aoife M Brennan

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1

Hyun-Seuk Moon

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Geetha H Mylvaganam

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6 August 2017

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Christina G Fiorenza

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Giuseppe Matarese

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Xiaowen Liu

5

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6 August 2017

Luisa Abanni

8

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Catherine J Williams

10

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6 August 2017

Alex M De Paoli

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6 August 2017

language of work or name

English

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publication date

1 June 2011

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6 August 2017

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6 August 2017

volume

60

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6 August 2017

issue

6

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6 August 2017

page(s)

1647-1656

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

6 August 2017

copyright license

start time

27 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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1 reference

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Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin

8 July 2018

1 reference

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Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation

8 July 2018

1 reference

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Leptin inhibits rosiglitazone-induced adipogenesis in murine primary adipocytes

8 July 2018

1 reference

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The blood-brain barrier as a cause of obesity

8 July 2018

1 reference

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Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

8 July 2018

1 reference

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Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines

8 July 2018

1 reference

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Signal integration in the endoplasmic reticulum unfolded protein response

8 July 2018

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Gene expression omnibus: microarray data storage, submission, retrieval, and analysis

8 July 2018

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Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

8 July 2018

1 reference

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Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes

8 July 2018

1 reference

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Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.

8 July 2018

1 reference

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Recombinant human leptin in women with hypothalamic amenorrhea.

8 July 2018

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Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g

8 July 2018

1 reference

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Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes

8 July 2018

1 reference

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Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin.

25 October 2018

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Endoplasmic reticulum stress plays a central role in development of leptin resistance

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

Leptin enhances human beta-defensin-2 production in human keratinocytes

25 October 2018

1 reference

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Leptin transport across the blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

Leptin-replacement therapy for lipodystrophy.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3114380

W(h)ither metreleptin for lipodystrophy and the metabolic syndrome?

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21617185

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB10-1791

1 reference

6 August 2017

1 reference

6 August 2017

1 reference