Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway (Q35040981)

6 August 2017

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title

Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway (English)

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6 August 2017

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Mark R Middleton

1

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6 August 2017

Geoffrey P Margison

series ordinal

2

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6 August 2017

publication date

1 January 2003

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Lancet Oncology Commission

6 August 2017

published in

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6 August 2017

volume

4

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6 August 2017

issue

1

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6 August 2017

page(s)

37-44

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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

6 August 2017

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Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

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7 January 2021

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7 January 2021

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7 January 2021

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma

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7 January 2021

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

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O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy

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7 January 2021

Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer

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7 January 2021

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7 January 2021

Inter- and intracellular heterogeneity of O6-alkylguanine-DNA alkyltransferase expression in human brain tumors: possible significance in nitrosourea therapy

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7 January 2021

O6-methylguanine-DNA methyltransferase activity in human liver tumors.

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7 January 2021

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7 January 2021

Understanding and manipulating O6-methylguanine-DNA methyltransferase expression

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7 January 2021

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7 January 2021

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

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7 January 2021

O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.

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7 January 2021

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

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7 January 2021

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

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7 January 2021

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7 January 2021

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

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7 January 2021

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7 January 2021

Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships

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7 January 2021

Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases

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7 January 2021

Clinical relevance of MGMT in the treatment of cancer

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7 January 2021

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase

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7 January 2021

O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives

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7 January 2021

10.1016/S1470-2045(03)00959-8

Identifiers

DOI

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6 August 2017

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