Transgenesis applied to transmissible spongiform encephalopathies (Q35037396)

5 August 2017

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title

Transgenesis applied to transmissible spongiform encephalopathies (English)

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5 August 2017

Jean-Luc Vilotte

1

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5 August 2017

Hubert Laude

series ordinal

2

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5 August 2017

publication date

1 December 2002

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5 August 2017

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5 August 2017

volume

11

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5 August 2017

issue

6

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5 August 2017

page(s)

547-564

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Prion diseases of humans and animals: their causes and molecular basis

5 August 2017

cites work

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12 December 2020

Altered circadian activity rhythms and sleep in mice devoid of prion protein

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12 December 2020

Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrP(C).

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12 December 2020

Prions prevent neuronal cell-line death.

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12 December 2020

Mice devoid of PrP are resistant to scrapie

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12 December 2020

Doxycycline control of prion protein transgene expression modulates prion disease in mice

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12 December 2020

Transgenic analysis of prion diseases

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12 December 2020

Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie

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12 December 2020

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein

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12 December 2020

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

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12 December 2020

Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene

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12 December 2020

Normal host prion protein necessary for scrapie-induced neurotoxicity

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12 December 2020

Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.

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12 December 2020

Prion protein genes and prion diseases: studies in transgenic mice

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12 December 2020

Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication

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12 December 2020

Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

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12 December 2020

New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives

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12 December 2020

N-terminally tagged prion protein supports prion propagation in transgenic mice

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12 December 2020

Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov.

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12 December 2020

Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice

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12 December 2020

Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss

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12 December 2020

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

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12 December 2020

Genome-wide search for markers associated with bovine spongiform encephalopathy.

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12 December 2020

Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein

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12 December 2020

Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice

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12 December 2020

Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

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12 December 2020

Two different neurodegenerative diseases caused by proteins with similar structures

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12 December 2020

B lymphocytes in prion neuroinvasion: central or peripheral players?

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12 December 2020

Binding of disease-associated prion protein to plasminogen

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12 December 2020

Transgenetics and gene targeting in studies of prion diseases

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12 December 2020

Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent

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12 December 2020

Bovine prion protein as a modulator of protein kinase CK2

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12 December 2020

Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies

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12 December 2020

Doppel-induced cerebellar degeneration in transgenic mice

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12 December 2020

Transmissible mink encephalopathy (TME) in Chinese hamsters: identification of two strains of TME and comparisons with scrapie

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12 December 2020

Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

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12 December 2020

Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent

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12 December 2020

Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration

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12 December 2020

PrP expression in B lymphocytes is not required for prion neuroinvasion

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12 December 2020

Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease

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12 December 2020

Unaltered susceptibility to BSE in transgenic mice expressing human prion protein.

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12 December 2020

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

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12 December 2020

Two alleles of a neural protein gene linked to scrapie in sheep

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12 December 2020

Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans

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12 December 2020

Recombinant scrapie-like prion protein of 106 amino acids is soluble

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12 December 2020

Transgenic and knockout mice in research on prion diseases

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12 December 2020

Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain

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12 December 2020

Prion protein is necessary for normal synaptic function

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12 December 2020

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

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12 December 2020

Identification of two prion protein regions that modify scrapie incubation time

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12 December 2020

Linkage of prion protein and scrapie incubation time genes

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12 December 2020

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.

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12 December 2020

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

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12 December 2020

Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice

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12 December 2020

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

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12 December 2020

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion

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12 December 2020

Prions in skeletal muscle

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12 December 2020

Species-barrier-independent prion replication in apparently resistant species

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12 December 2020

PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion

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12 December 2020

A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination

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12 December 2020

Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers

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12 December 2020

Genomic interval engineering of mice identifies a novel modulator of triglyceride production

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12 December 2020

Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions

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12 December 2020

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

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12 December 2020

Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.

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12 December 2020

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

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12 December 2020

NMR characterization of the full‐length recombinant murine prion protein, mPrP(23–231)

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12 December 2020

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

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12 December 2020

PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie

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12 December 2020

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

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12 December 2020

Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein

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12 December 2020

The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.

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12 December 2020

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

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12 December 2020

Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein

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12 December 2020

Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans

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12 December 2020

The same prion strain causes vCJD and BSE

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12 December 2020

Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix

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12 December 2020

A transmembrane form of the prion protein in neurodegenerative disease

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12 December 2020

Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome

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12 December 2020

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology

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12 December 2020

Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice

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12 December 2020

A crucial role for B cells in neuroinvasive scrapie.

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12 December 2020

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice

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12 December 2020

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

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12 December 2020

Prion infection impairs the cellular response to oxidative stress

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12 December 2020

Functional screening of an asthma QTL in YAC transgenic mice.

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12 December 2020

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie

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12 December 2020

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

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12 December 2020

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice

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12 December 2020

Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells

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12 December 2020

Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen

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12 December 2020

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

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12 December 2020

Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep

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12 December 2020

Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

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12 December 2020

Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.

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12 December 2020

Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

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12 December 2020

Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene

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12 December 2020

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

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12 December 2020

PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain

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12 December 2020

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.

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12 December 2020

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

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12 December 2020

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

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12 December 2020

Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel

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12 December 2020

Brain copper content and cuproenzyme activity do not vary with prion protein expression level

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12 December 2020

PrPSc-like prion protein peptide inhibits the function of cellular prion protein

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12 December 2020

Selective neuronal targeting in prion disease

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12 December 2020

The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells

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12 December 2020

Spongiform encephalopathies: insights from transgenic models

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12 December 2020

No propagation of prions in mice devoid of PrP.

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12 December 2020

The prion gene complex encoding PrP(C) and Doppel: insights from mutational analysis

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12 December 2020

Transgenic studies of the influence of the PrP structure on TSE diseases.

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12 December 2020

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

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12 December 2020

Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice

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12 December 2020

Novel proteinaceous infectious particles cause scrapie

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12 December 2020

Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein

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12 December 2020

Complement facilitates early prion pathogenesis

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12 December 2020

Propagation of prion strains through specific conformers of the prion protein

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12 December 2020

Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.

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12 December 2020

Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells.

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12 December 2020

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

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12 December 2020

Molecular biology of prion diseases

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12 December 2020

PrP gene dosage and long term potentiation

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12 December 2020

GENETICAL CONTROL OF THE INCUBATION PERIOD IN MICE OF THE NEUROLOGICAL DISEASE, SCRAPIE

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12 December 2020

Scrapie prion proteins are synthesized in neurons

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12 December 2020

A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

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12 December 2020

Identification of multiple quantitative trait loci linked to prion disease incubation period in mice

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12 December 2020

Molecular genetics of transmissible spongiform encephalopathies

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12 December 2020

Signal transduction through prion protein

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12 December 2020

A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.

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12 December 2020

Molecular biology of prion propagation.

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12 December 2020

Chimeric prion protein expression in cultured cells and transgenic mice

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12 December 2020

Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent

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12 December 2020

Double Replacement Gene Targeting for the Production of a Series of Mouse Strains with Different Prion Protein Gene Alterations

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12 December 2020

Perspectives: neurobiology. PrP's double causes trouble

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12 December 2020

Quantitative trait loci affecting prion incubation time in mice

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12 December 2020

Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins

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12 December 2020

Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters

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12 December 2020

Neuroinvasion by a Creutzfeldt-Jakob disease agent in the absence of B cells and follicular dendritic cells

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12 December 2020

Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

Identifiers

DOI

10.1023/A:1021125510220

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Dimensions Publication ID

5 August 2017

1006871118

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