The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. (Q35036600)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560 AND SRC:MED&resulttype=core&format=json

16 December 2019

review article

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title

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560 AND SRC:MED&resulttype=core&format=json

16 December 2019

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1

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16 December 2019

Peter J. Ratcliffe

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560 AND SRC:MED&resulttype=core&format=json

16 December 2019

author name string

Christopher William Pugh

series ordinal

1

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5 August 2017

publication date

1 February 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560 AND SRC:MED&resulttype=core&format=json

Seminars in Cancer Biology

16 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560 AND SRC:MED&resulttype=core&format=json

16 December 2019

volume

13

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16 December 2019

issue

1

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16 December 2019

page(s)

83-89

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The VHL tumour-suppressor gene paradigm

16 December 2019

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A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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Comparative sequence analysis of the VHL tumor suppressor gene

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

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7 January 2021

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The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis

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The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

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7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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7 January 2021

10.1016/S1044-579X(02)00103-7

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507560 AND SRC:MED&resulttype=core&format=json

16 December 2019

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