Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo (Q35023290)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12732730 AND SRC:MED&resulttype=core&format=json

3 November 2019

title

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo (English)

1 reference

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3 November 2019

3

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3 November 2019

author name string

Bonnie C Miller

1

1 reference

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3 November 2019

Elizabeth A Eckman

2

1 reference

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3 November 2019

Nicole Dobbs

4

1 reference

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3 November 2019

K Martin Chow

5

1 reference

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3 November 2019

Christopher B Eckman

6

1 reference

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3 November 2019

Louis B Hersh

7

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3 November 2019

Dwain L Thiele

8

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3 November 2019

language of work or name

English

0 references

publication date

5 May 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12732730 AND SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

3 November 2019

published in

1 reference

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3 November 2019

volume

100

1 reference

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3 November 2019

issue

10

1 reference

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3 November 2019

page(s)

6221-6226

1 reference

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describes a project that uses

3 November 2019

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC156353/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Regulation of amyloid beta-peptide levels by enzymatic degradation.

8 July 2018

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Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

8 July 2018

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

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Regulation of APP cleavage by alpha-, beta- and gamma-secretases

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Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

8 July 2018

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

8 July 2018

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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44 Insulysin and pitrilysin: Insulin-degrading enzymes of mammals and bacteria

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PubMed

https://pubmed.ncbi.nlm.nih.gov/12732730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Insulinase, insulinase-inhibitors, and diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12732730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1031520100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12732730 AND SRC:MED&resulttype=core&format=json

3 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12732730 AND SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

12732730

1 reference