Cyclooxygenase-2 inhibitors: promise or peril? (Q35017693)

5 August 2017

4 references

28 September 2019

2 October 2019

21 December 2019

19 July 2021

Cyclooxygenase-2 inhibitors: promise or peril? (English)

1 reference

5 August 2017

1 reference

28 September 2019

1 reference

2 October 2019

1 reference

21 December 2019

anti-inflammatory agent

1 reference

19 July 2021

Laurel J Mengle-Gaw

1

1 reference

5 August 2017

Benjamin D Schwartz

series ordinal

2

1 reference

5 August 2017

publication date

1 October 2002

5 references

Mediators of Inflammation

5 August 2017

28 September 2019

2 October 2019

21 December 2019

19 July 2021

5 references

5 August 2017

28 September 2019

2 October 2019

21 December 2019

19 July 2021

11

1 reference

5 August 2017

issue

5

1 reference

5 August 2017

page(s)

275-286

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Creative Commons Attribution 3.0 Unported

5 August 2017

copyright license

start time

1 January 2002

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

Comparison of thromboembolic events in patients treated with celecoxib, a cyclooxygenase-2 specific inhibitor, versus ibuprofen or diclofenac

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Cyclooxygenase inhibitors and the antiplatelet effects of aspirin

8 July 2018

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Acetaminophen, aspirin, and chronic renal failure

8 July 2018

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Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

8 July 2018

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Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

8 July 2018

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Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study

8 July 2018

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Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity?

8 July 2018

1 reference

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Rofecoxib, a specific cyclooxygenase-2 inhibitor, in primary dysmenorrhea: a randomized controlled trial

8 July 2018

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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

8 July 2018

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Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans.

8 July 2018

1 reference

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Effects of nonsteroidal anti-inflammatory therapy on platelets

8 July 2018

1 reference

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The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice

8 July 2018

1 reference

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Kinetic basis for selective inhibition of cyclo-oxygenases

8 July 2018

1 reference

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Angiotensin II attenuates renal cortical cyclooxygenase-2 expression

8 July 2018

1 reference

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Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2

8 July 2018

1 reference

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Pharmacological analysis of cyclooxygenase-1 in inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Cyclooxygenase in biology and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Effects of Meloxicam, Compared with other NSAIDs, on Cartilage Proteoglycan Metabolism, Synovial Prostaglandin E2, and Production of Interleukins 1, 6 and 8, in Human and Porcine Explants in Organ Culture

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Pain management in osteoarthritis: the role of COX-2 inhibitors

8 July 2018

1 reference

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COX-1 and COX-2 tissue expression: implications and predictions

8 July 2018

1 reference

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Consumption of non‐steroidal anti‐inflammatory drugs and the development of functional renal impairment in elderly subjects. Results of a case‐control study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Colorectal cancer and nonsteroidal anti-inflammatory drugs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

8 July 2018

1 reference

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Risk of Alzheimer's disease and duration of NSAID use.

8 July 2018

1 reference

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Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

The mechanisms of action of NSAIDs in analgesia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Platelets and shear stress.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

New pharmacological strategies for pain relief

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Yes, but do they still get headaches?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Effects of nonsteroidal antiinflammatory drugs on bone loss in chronic inflammatory disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

The role of prostaglandins in the regulation of bone metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Further evidence implicating prostaglandin E2 in the genesis of pyrogen fever

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Role of endogenous prostaglandins in preventing gastrointestinal ulceration: induction of ulcers by antibodies to prostaglandins.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Effect of non-steroidal anti-inflammatory drugs on the course of osteoarthritis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

An updated safety profile of etodolac in several thousand patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Aspirin use and reduced risk of fatal colon cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

The treatment of osteoarthritis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Non-steroid anti-inflammatory drugs: Influence of extra-cellular pH on biodistribution and pharmacological effects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

A comparison of renal-related adverse drug reactions between rofecoxib and celecoxib, based on the World Health Organization/Uppsala Monitoring Centre safety database

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Clinical trial of indomethacin in Alzheimer's disease.

25 October 2018

1 reference

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Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease.

25 October 2018

1 reference

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Sulindac for polyposis of the colon.

25 October 2018

1 reference

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Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781678

Long-Term Treatment of Indomethacin Reduces Vertebral Bone Mass and Strength in Ovariectomized Rats

9 December 2018

1 reference

12 December 2020

Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2

1 reference

12 December 2020

Bone mineral density and biomechanical properties of spine and femur of ovariectomized rats treated with naproxen

1 reference

12 December 2020

Effects of nonsteroidal anti-inflammatory drugs and prostaglandins on osteoblastic functions

1 reference

12 December 2020

High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors

1 reference

12 December 2020

Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans

1 reference

12 December 2020

Acute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factors

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12 December 2020

Safety of meloxicam: a global analysis of clinical trials

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12 December 2020

Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation

1 reference

12 December 2020

Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis

1 reference

12 December 2020

Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway.

1 reference

12 December 2020

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1 reference

12 December 2020

Expression and regulation of cyclooxygenase-2 in rat microglia

1 reference

12 December 2020

10.1080/09629350295000041

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference