Granzymes and perforin in solid organ transplant rejection (Q35010452)

5 August 2017

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title

Granzymes and perforin in solid organ transplant rejection (English)

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5 August 2017

J C Choy

1

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5 August 2017

publication date

30 October 2009

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Cell Death & Differentiation

5 August 2017

published in

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5 August 2017

volume

17

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5 August 2017

issue

4

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5 August 2017

page(s)

567-576

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Minimizing immunosuppression, an alternative approach to reducing side effects: objectives and interim result

5 August 2017

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Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells

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Perforin-mediated target-cell death and immune homeostasis

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

21 January 2018

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Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

21 January 2018

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Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

21 January 2018

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Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

21 January 2018

1 reference

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

21 January 2018

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Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

21 January 2018

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The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

21 January 2018

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https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

21 January 2018

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Cell death induced by granzyme C.

21 January 2018

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Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

21 January 2018

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

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Immune function in mice lacking the perforin gene

21 January 2018

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A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

21 January 2018

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An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8 T cells and interferon gamma are essential for the disorder

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Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses

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Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.

21 January 2018

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

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https://api.crossref.org/works/10.1038/CDD.2009.161

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Human and mouse granzyme A induce a proinflammatory cytokine response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Phenotypic and functional characterization of cytotoxic cells derived from endomyocardial biopsies in human cardiac allografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients

21 January 2018

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https://api.crossref.org/works/10.1038/CDD.2009.161

In search of the 'missing self': MHC molecules and NK cell recognition

21 January 2018

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https://api.crossref.org/works/10.1038/CDD.2009.161

Expression of the cytotoxic T cell mediator granzyme B during liver allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Effects of purified perforin and granzyme A from cytotoxic T lymphocytes on guinea pig ventricular myocytes

21 January 2018

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https://api.crossref.org/works/10.1038/CDD.2009.161

Mechanisms of lymphocyte-mediated cytotoxicity in acute renal allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme C supports efficient CTL-mediated killing late in primary alloimmune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Nephritogenic T cells use granzyme C as a cytotoxic mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Induction of inducible NO synthase in bystander human T cells increases allogeneic responses in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Donor heart endothelial cells as targets for graft infiltrating lymphocytes after clinical cardiac transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Porcine endothelial cells, unlike human endothelial cells, can be killed by human CTL via Fas ligand and cannot be protected by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Vascular endothelium does not activate CD4 direct allorecognition in graft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

A constitutive cytoprotective pathway protects endothelial cells from lipopolysaccharide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Bcl-2 transduction protects human endothelial cell synthetic microvessel grafts from allogeneic T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

IFN-gamma prevents early perforin-granzyme-mediated destruction of kidney allografts by inducing donor class I products in the kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Antibody-mediated rejection: treatment alternatives and outcomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Acute antibody-mediated rejection following heart transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Aortic allograft vasculopathy is mediated by CD8( ) T cells in Cyclosporin A immunosuppressed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Non-classical pathways of cell-mediated allograft rejection: new challenges for tolerance induction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Vascular remodeling in transplant vasculopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Immunologic basis of transplant-associated arteriosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Interferon-gamma axis in graft arteriosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

The regulation and consequences of immune-mediated cell death in atheromatous diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Cytotoxic molecule mRNA expression in chronically rejected human kidney allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Diagnosis of acute renal allograft rejection by analyzing whole blood mRNA expression of lymphocyte marker molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Detection of cardiac allograft rejection by real-time PCR analysis of circulating mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

The transcriptome of human cytotoxic T cells: measuring the burden of CTL-associated transcripts in human kidney transplants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Cutting edge: contact-mediated suppression by CD4 CD25 regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Transplantation survival is maintained by granzyme B regulatory cells and adaptive regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Granzyme A and perforin as markers for rejection in cardiac transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult heart transplantation report--2006

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Role of CD4 and CD8 T cells in murine skin and heart allograft rejection across different antigenic desparities

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28−/− mice

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Early increased chemokine expression and production in murine allogeneic skin grafts is mediated by natural killer cells

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Perforin and granzyme B as markers for acute rejection in heart transplantation

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Granzyme B and perforin can be used as predictive markers of acute rejection in heart transplantation

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Donor-specific lysis of human kidney proximal tubular epithelial cells by renal allograft-infiltrating lymphocytes

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Acute rejection of vascular heart allografts by perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Inhibition of acute cardiac allograft rejection in immunoglobulin-deficient mice

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Cyclosporin A can switch the immune response induced by antigen from a humoral to a cell-mediated mode

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

The inhibitor cytokine interleukin-1 receptor antagonist synergistically augments cyclosporine immunosuppression in a rat cardiac allograft model

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

The pathogenesis of cardiac allograft vasculopathy

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Perforin expression localizing cytotoxic lymphocytes in the intimas of coronary arteries with transplant-related accelerated arteriosclerosis

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

CD8 T cells mediate aortic allograft vasculopathy by direct killing and an interferon-gamma-dependent indirect pathway

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Molecular executors of cell death--differential intrarenal expression of Fas ligand, Fas, granzyme B, and perforin during acute and/or chronic rejection of human renal allografts

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Risk factors for chronic rejection in renal allograft recipients.

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https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

1 reference

https://api.crossref.org/works/10.1038/CDD.2009.161

7 January 2021

Identifiers

DOI

10.1038/CDD.2009.161

1 reference

5 August 2017

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