UGT genomic diversity: beyond gene duplication (Q35009521)

5 August 2017

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title

UGT genomic diversity: beyond gene duplication (English)

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5 August 2017

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Chantal Guillemette

1

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ORCID Public Data File 2021

author name string

Eric Lévesque

2

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5 August 2017

Mario Harvey

3

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5 August 2017

Judith Bellemare

4

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5 August 2017

Vincent Menard

5

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5 August 2017

language of work or name

English

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publication date

1 February 2010

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5 August 2017

published in

Drug Metabolism Reviews

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5 August 2017

volume

42

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5 August 2017

issue

1

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5 August 2017

page(s)

24-44

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Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: identification of apoptotic genes as targets for demethylation

5 August 2017

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Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids

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Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues

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Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans

21 January 2018

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Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine

21 January 2018

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21 January 2018

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The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice

21 January 2018

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Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa

21 January 2018

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Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation

21 January 2018

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Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases

21 January 2018

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21 January 2018

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Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases

21 January 2018

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Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

21 January 2018

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Deep cap analysis gene expression (CAGE): genome-wide identification of promoters, quantification of their expression, and network inference

21 January 2018

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The UDP-glucuronosyltransferases as oligomeric enzymes

21 January 2018

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Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture

21 January 2018

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Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities.

21 January 2018

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Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms.

21 January 2018

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Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

21 January 2018

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Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.

21 January 2018

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Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expression

21 January 2018

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Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications

21 January 2018

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21 January 2018

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Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity

21 January 2018

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Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

21 January 2018

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Genomic and epigenetic instability in colorectal cancer pathogenesis

21 January 2018

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Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.

21 January 2018

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Pharmacogenomics of human UDP-glucuronosyltransferase enzymes

21 January 2018

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Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.

21 January 2018

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Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells

21 January 2018

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Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene

21 January 2018

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Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism

21 January 2018

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Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase

21 January 2018

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cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily

21 January 2018

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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

21 January 2018

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Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population

21 January 2018

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Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22

21 January 2018

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UDP-Glucuronosyltransferases

21 January 2018

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Promoter usage and alternative splicing

21 January 2018

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Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme.

21 January 2018

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The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers.

21 January 2018

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Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

21 January 2018

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Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.

21 January 2018

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Isolation and characterization of UGT2B15(Y85): a UDP glucuronosyltransferase encoded by a polymorphic gene

21 January 2018

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Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus

21 January 2018

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Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase

21 January 2018

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Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant.

21 January 2018

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Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

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Regulation of UDP glucuronosyltransferase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases.

21 January 2018

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The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

Alternative pre-mRNA splicing and proteome expansion in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Common deletion polymorphisms in the human genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Structure and function of uridine diphosphate glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Determinants of UDP Glucuronosyltransferase Membrane Association and Residency in the Endoplasmic Reticulum

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

Pre-mRNA processing reaches back to transcription and ahead to translation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

A human minor histocompatibility antigen resulting from differential expression due to a gene deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Multiple alternative splice isoforms of parathyroid hormone-related peptide mRNA in human cell lines

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

A new type of human calcitonin receptor isoform generated by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

The human UDP-glucuronosyltransferases: structural aspects and drug glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

UDP-glucuronosyltransferases: gene structures of UGT1 and UGT2 families

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer

21 January 2018

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Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

Structural and functional studies of UDP-glucuronosyltransferases

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

Structure of UDP-glucuronosyltransferases in membranes

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

Genomic organization of the UGT2b gene cluster on human chromosome 4q13.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives

21 January 2018

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In-depth query of large genomes using tiling arrays

21 January 2018

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Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Common genetic variants account for differences in gene expression among ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Regulation of alternative splicing by reversible protein phosphorylation

21 January 2018

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Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues

21 January 2018

1 reference

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Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602530903210682

Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction

21 January 2018

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https://api.crossref.org/works/10.3109/03602530903210682

Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver

21 January 2018

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

21 January 2018

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Glucuronidation Activity of the UGT2B17 Enzyme toward Xenobiotics

21 January 2018

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Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4.

21 January 2018

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Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

21 January 2018

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The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

21 January 2018

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Alternative isoform regulation in human tissue transcriptomes

21 January 2018

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The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription

21 January 2018

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RNA-Seq: a revolutionary tool for transcriptomics

21 January 2018

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Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

21 January 2018

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Adaptive evolution of UGT2B17 copy-number variation

21 January 2018

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Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis

21 January 2018

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Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice

21 January 2018

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Hepatocyte Nuclear Factor-1alpha Is a Causal Factor Responsible for Interindividual Differences in the Expression of UDP-Glucuronosyltransferase 2B7 mRNA in Human Livers

21 January 2018

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10.3109/03602530903210682

21 January 2018

Identifiers

DOI

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5 August 2017

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