Fast axonal transport misregulation and Alzheimer's disease (Q34995098)

5 August 2017

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title

Fast axonal transport misregulation and Alzheimer's disease (English)

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5 August 2017

Gerardo Morfini

1

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5 August 2017

Gustavo Pigino

2

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5 August 2017

Uwe Beffert

3

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5 August 2017

Jorge Busciglio

4

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5 August 2017

Scott T Brady

5

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5 August 2017

publication date

1 January 2002

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5 August 2017

published in

NeuroMolecular Medicine

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5 August 2017

volume

2

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5 August 2017

issue

2

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5 August 2017

page(s)

89-99

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

5 August 2017

cites work

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In vivo analysis of wild-type and FTDP-17 tau transgenic mice.

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12 December 2020

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

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Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

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Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

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Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

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Suppression of KIF2 in PC12 Cells Alters the Distribution of a Growth Cone Nonsynaptic Membrane Receptor and Inhibits Neurite Extension

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Judging a protein by more than its name: GSK-3.

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Molecular motors in axonal transport. Cellular and molecular biology of kinesin

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Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

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Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

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12 December 2020

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

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12 December 2020

Apolipoprotein E activates Akt pathway in neuro-2a in an isoform-specific manner

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12 December 2020

Fast axonal transport of kinesin in the rat visual system: functionality of kinesin heavy chain isoforms

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12 December 2020

Kinesin interactions with membrane bounded organelles in vivo and in vitro

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12 December 2020

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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12 December 2020

Phosphorylation-dependent inhibition by synapsin I of organelle movement in squid axoplasm.

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A Specific Light Chain of Kinesin Associates with Mitochondria in Cultured Cells

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

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12 December 2020

Altered microtubule organization in small-calibre axons of mice lacking tau protein

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12 December 2020

DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

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12 December 2020

Phosphorylation of kinesin in vivo correlates with organelle association and neurite outgrowth

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12 December 2020

Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons

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12 December 2020

Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation

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12 December 2020

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

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Alzheimer's disease. The tangled tale of tau.

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A kinesin medley: biochemical and functional heterogeneity

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Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing

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GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis

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12 December 2020

GTP gamma S inhibits organelle transport along axonal microtubules

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12 December 2020

Neurofibrillary tangles and tau phosphorylation.

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12 December 2020

Biochemical and functional diversity of microtubule motors in the nervous system

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12 December 2020

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice

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12 December 2020

Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta

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12 December 2020

Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

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12 December 2020

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

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12 December 2020

Frequency oftau mutations in three series of non-Alzheimer's degenerative dementia

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12 December 2020

Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

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Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

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12 December 2020

The presenilins in Alzheimer's disease--proteolysis holds the key.

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12 December 2020

Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP.

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beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins

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12 December 2020

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

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12 December 2020

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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12 December 2020

Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism

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12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons

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12 December 2020

Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

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12 December 2020

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

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12 December 2020

Integrins stimulate phosphorylation of neurofilament NF-M subunit KSP repeats through activation of extracellular regulated-kinases (Erk1/Erk2) in cultured motoneurons and transfected NIH 3T3 cells

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12 December 2020

A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein

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12 December 2020

On the structure of microtubules, tau, and paired helical filaments

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12 December 2020

Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

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12 December 2020

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

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12 December 2020

Regulation of kinesin: implications for neuronal development

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12 December 2020

A novel brain ATPase with properties expected for the fast axonal transport motor

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12 December 2020

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

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12 December 2020

In vivo activation and nuclear translocation of phosphorylated glycogen synthase kinase-3beta in neuronal apoptosis: links to tau phosphorylation.

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12 December 2020

Glycogen synthase kinase 3: an emerging therapeutic target

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12 December 2020

Tau and transgenic animal models

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12 December 2020

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

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12 December 2020

Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis

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12 December 2020

Regulation and functions of the glycogen synthase kinase-3 subfamily

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12 December 2020

Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides.

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12 December 2020

Immunochemical analysis of kinesin light chain function

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12 December 2020

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain

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12 December 2020

Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta

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12 December 2020

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein

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12 December 2020

Release of kinesin from vesicles by hsc70 and regulation of fast axonal transport

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12 December 2020

Glycogen synthase kinase-3: functions in oncogenesis and development

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12 December 2020

Pancreastatin, a chromogranin-A-derived peptide, inhibits insulin-stimulated glycogen synthesis by activating GSK-3 in rat adipocytes.

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12 December 2020

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

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12 December 2020

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

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12 December 2020

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

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12 December 2020

Copurification of kinesin polypeptides with microtubule-stimulated Mg-ATPase activity and kinetic analysis of enzymatic properties

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12 December 2020

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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12 December 2020

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants

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12 December 2020

Identifiers

DOI

10.1385/NMM:2:2:089

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Dimensions Publication ID

5 August 2017

1018503910

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