The future challenges facing the development of new antimicrobial drugs. (Q34988239)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

review article

1 reference

title

The future challenges facing the development of new antimicrobial drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

author name string

Anthony Coates

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

Yanmin Hu

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

Richard Bax

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

publication date

1 November 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

14 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

14 December 2019

page(s)

895-910

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12415249 AND SRC:MED&resulttype=core&format=json

PNEUMOCOCCAL BACTEREMIA WITH ESPECIAL REFERENCE TO BACTEREMIC PNEUMOCOCCAL PNEUMONIA

14 December 2019

cites work

1 reference

Tuberculous peritonitis: 43 years' expereince in diagnosis and treatment

31 March 2020

1 reference

Antibiotic resistance--what can we do?

31 March 2020

1 reference

Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: results from the TRUST Surveillance Program, 1999-2000.

31 March 2020

1 reference

Novelties in the field of anti-infective compounds in 1999.

31 March 2020

1 reference

The millennium bugs--the need for and development of new antibacterials

31 March 2020

1 reference

New approaches to the control of infections caused by antibiotic-resistant bacteria. An industry perspective

31 March 2020

1 reference

Regulating the use of antibiotics in the community

31 March 2020

1 reference

Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines

31 March 2020

1 reference

Antibiotic clinical trials revisited

31 March 2020

1 reference

Mechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compound

31 March 2020

1 reference

Linezolid resistance in a clinical isolate of Staphylococcus aureus

31 March 2020

1 reference

Molecular mechanisms that confer antibacterial drug resistance

31 March 2020

1 reference

Biochemical and genetical approaches to the mechanism of action of penicillin

31 March 2020

1 reference

The mode of action of 4-quinolones and possible mechanisms of resistance

31 March 2020

1 reference

Interaction of rifamycin with bacterial RNA polymerase

31 March 2020

1 reference

Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria

31 March 2020

1 reference

Recovery of resistance (R) factors from a drug-free community.

31 March 2020

1 reference

Mechanisms of antimicrobial resistance: their clinical relevance in the new millennium

31 March 2020

1 reference

Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics

31 March 2020

1 reference

Resistance to antibiotics mediated by target alterations

31 March 2020

1 reference

Strategies to control antibiotic resistance

31 March 2020

1 reference

Antibiotic use and Escherichia coli resistance trends for quinolones and cotrimoxazole in Sweden

31 March 2020

1 reference

Antimicrobial-drug resistance

31 March 2020

1 reference

The beta-lactamases of gram-negative bacteria and their role in resistance to beta-lactam antibiotics

31 March 2020

1 reference

More extended-spectrum beta-lactamases

31 March 2020

1 reference

R-factor Mediated Dihydrofolate Reductases which Confer Trimethoprim Resistance

31 March 2020

1 reference

Interplay of impermeability and chromosomal beta-lactamase activity in imipenem-resistant Pseudomonas aeruginosa

31 March 2020

1 reference

Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials

31 March 2020

1 reference

The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance

31 March 2020

1 reference

Detection of penicillin tolerance in Streptococcus pyogenes

31 March 2020

1 reference

Tolerance of Pseudomonas aeruginosa to killing by ciprofloxacin, gentamicin and imipenem in vitro and in vivo

31 March 2020

1 reference

Increased levels of sigJ mRNA in late stationary phase cultures of Mycobacterium tuberculosis detected by DNA array hybridisation

31 March 2020

1 reference

Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide

31 March 2020

1 reference

How many antibiotics are produced by the genus Streptomyces?

31 March 2020

1 reference

Screening of natural products for antimicrobial agents.

31 March 2020

1 reference

Innate antimicrobial peptide protects the skin from invasive bacterial infection

31 March 2020

1 reference

New strategies for antibacterial drug design

31 March 2020

1 reference

Discovery and development of new antimicrobial agents

31 March 2020

1 reference

Irreversible Effects of Serum Proteins on Beta-Lactam Antibiotics

31 March 2020

1 reference

Production of ‘hybrid’ antibiotics by genetic engineering

31 March 2020

1 reference

Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain

31 March 2020

1 reference

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

31 March 2020

1 reference

Constructing polyketides: from collie to combinatorial biosynthesis

31 March 2020

1 reference

Harnessing the biosynthetic code: combinations, permutations, and mutations

31 March 2020

1 reference

Genetic engineering of Streptomyces to create hybrid antibiotics

31 March 2020

1 reference

Biomimetic synthesis and optimization of cyclic peptide antibiotics

31 March 2020

1 reference

Finding drug targets in microbial genomes

31 March 2020

1 reference

New antibiotic discovery, novel screens, novel targets and impact of microbial genomics

31 March 2020

1 reference

Harnessing the power of the genome in the search for new antibiotics

31 March 2020

1 reference

Will genomics revolutionize antimicrobial drug discovery?

31 March 2020

1 reference

Novel targets for the future development of antibacterial agents

31 March 2020

1 reference

Exploiting current understanding of antibiotic action for discovery of new drugs.

31 March 2020

1 reference

Exploiting genomics to discover new antibiotics

31 March 2020

1 reference

Quorum sensing and starvation: signals for entry into stationary phase

31 March 2020

1 reference

What is finished, and why does it matter

31 March 2020

1 reference

Bactericidal antisense effects of peptide-PNA conjugates.

31 March 2020

1 reference

The bacterial cell wall as a source of antibacterial targets

31 March 2020

1 reference

Maximum shields: the assembly and function of the bacterial spore coat

31 March 2020

1 reference

Assembly and genetics of spore protective structures

31 March 2020

1 reference

31 March 2020

1 reference

Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor

31 March 2020

1 reference

Factors affecting the selection and use of tetrazolium salts as cytochemical indicators of microbial viability and activity

31 March 2020

1 reference

Bacillus subtilis sporulation and stationary phase gene expression

31 March 2020

1 reference

Not quite dead enough: on bacterial life, culturability, senescence, and death

31 March 2020

1 reference

The starvation-stress response (SSR) of Salmonella.

31 March 2020

1 reference

Back to log phase: sigma S as a global regulator in the osmotic control of gene expression in Escherichia coli

31 March 2020

1 reference

Riddle of biofilm resistance

31 March 2020

1 reference

Bactericidal action of ofloxacin, sulbactam-ampicillin, rifampin, and isoniazid on logarithmic- and stationary-phase cultures of Mycobacterium tuberculosis.

31 March 2020

1 reference

Effect of antibiotics on non-growing planktonic cells and biofilms of Escherichia coli.

31 March 2020

1 reference

Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissues

31 March 2020

1 reference

Antibiotic duration for treating uncomplicated, symptomatic lower urinary tract infections in elderly women.

31 March 2020

1 reference

Induction of autolysis in nongrowing Escherichia coli

31 March 2020

1 reference

Carriage of antibiotic-resistant fecal bacteria in Nepal reflects proximity to Kathmandu

31 March 2020

1 reference

Carriage of antibiotic-resistant bacteria by healthy children

31 March 2020

1 reference

The prevalence of antibiotic-resistant faecal Escherichia coli in healthy volunteers in Venezuela

31 March 2020

1 reference

β-Lactam resistance in normal faecal flora from South Africa

31 March 2020

1 reference

Antibiotic resistance of Escherichia coli in fecal samples of healthy people in two different areas in an industrialized country.

31 March 2020

1 reference

Characteristics of Antibiotic-Resistant Escherichia Coli In the Rectum of Healthy School-Children

31 March 2020

1 reference

Parenteral antibiotic therapy in the treatment of lower respiratory tract infections. Strategies to minimize the development of antibiotic resistance

31 March 2020

1 reference

Don't keep taking the tablets?

31 March 2020

1 reference

Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window

31 March 2020

1 reference

Mutation frequencies and antibiotic resistance

31 March 2020

1 reference

cAMP-dependent SOS induction and mutagenesis in resting bacterial populations.

31 March 2020

1 reference

Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates

31 March 2020

1 reference

Adaptive mutations produce resistance to ciprofloxacin.

31 March 2020

1 reference

Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa.

31 March 2020

1 reference

Safeguarding future antimicrobial options: strategies to minimize resistance

31 March 2020

1 reference

Pneumococcal resistance patterns in Europe

31 March 2020

1 reference

Antibiotic therapy of community respiratory tract infections: strategies for optimal outcomes and minimized resistance emergence

31 March 2020

1 reference

Animal model pharmacokinetics and pharmacodynamics: a critical review

31 March 2020

1 reference

Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

31 March 2020

1 reference

Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients

31 March 2020

1 reference

Hospital-acquired pneumonia: risk factors, microbiology, and treatment

31 March 2020

1 reference

The treatment of respiratory pseudomonas infection in cystic fibrosis: what drug and which way?

31 March 2020

1 reference

Metronidazole containing quadruple therapy for infection with metronidazole resistant Helicobacter pylori: a prospective study

31 March 2020

1 reference

Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients.

31 March 2020

1 reference

Combination therapy as a tool to prevent emergence of bacterial resistance

31 March 2020

1 reference

Cotrimoxazole. Rationale for re-examining its indications for use.

31 March 2020

1 reference

Addressing antibiotic resistance

31 March 2020

1 reference

Increased expression of the multidrug efflux genes acrAB occurs during slow growth of Escherichia coli.

31 March 2020

1 reference

Starvation-induced expression of SspA and SspB: the effects of a null mutation in sspA on Escherichia coli protein synthesis and survival during growth and prolonged starvation.

31 March 2020

1 reference

The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage

31 March 2020

1 reference

RNA expression analysis using a 30 base pair resolution Escherichia coli genome array

31 March 2020

1 reference

Nonreplicating persistence of mycobacterium tuberculosis

31 March 2020

1 reference

Current status and future development of antitubercular chemotherapy

31 March 2020

1 reference

Programmed death in bacteria

31 March 2020

1 reference

Emergence of vancomycin tolerance in Streptococcus pneumoniae

31 March 2020

1 reference

Bactericidal activities of five quinolones for Escherichia coli strains with mutations in genes encoding the SOS response or cell division

31 March 2020

1 reference

Direct correlation between overproduction of guanosine 3',5'-bispyrophosphate (ppGpp) and penicillin tolerance in Escherichia coli

31 March 2020

1 reference

hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis

31 March 2020

1 reference