Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice (Q34982321)

5 August 2017

title

Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice (English)

1 reference

5 August 2017

4

John J Kopchick

1 reference

5 August 2017

3

Edward O List

1 reference

5 August 2017

6

Richard A Miller

1 reference

5 August 2017

Graham Dominick

1

1 reference

5 August 2017

Darlene E Berryman

series ordinal

2

1 reference

5 August 2017

Xinna Li

series ordinal

5

1 reference

5 August 2017

Gonzalo G Garcia

series ordinal

7

1 reference

5 August 2017

language of work or name

English

0 references

publication date

2 December 2014

1 reference

5 August 2017

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5 August 2017

volume

156

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5 August 2017

issue

2

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5 August 2017

page(s)

565-575

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Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

5 August 2017

cites work

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8 July 2018

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Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent

8 July 2018

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Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

8 July 2018

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Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

8 July 2018

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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

8 July 2018

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

8 July 2018

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Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

8 July 2018

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Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function

8 July 2018

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Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

8 July 2018

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Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes

8 July 2018

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Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism

8 July 2018

1 reference

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The GH/IGF-1 axis in ageing and longevity

8 July 2018

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Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?.

8 July 2018

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Duration of rapamycin treatment has differential effects on metabolism in mice

8 July 2018

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The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer

8 July 2018

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The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice

8 July 2018

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mTOR in aging, metabolism, and cancer

8 July 2018

1 reference

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Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae

8 July 2018

1 reference

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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

8 July 2018

1 reference

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

8 July 2018

1 reference

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

8 July 2018

1 reference

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Igf-I signaling and effects on longevity

8 July 2018

1 reference

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The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

mTORC2 targets AGC kinases through Sin1-dependent recruitment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Oxidative stress, inflamm-aging and immunosenescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

mTOR complex 2 signaling and functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Role of mTOR signaling in tumor cell motility, invasion and metastasis

8 July 2018

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

8 July 2018

1 reference

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Single-gene mutations and healthy ageing in mammals

8 July 2018

1 reference

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TOR and ageing: a complex pathway for a complex process.

8 July 2018

1 reference

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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

8 July 2018

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Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

8 July 2018

1 reference

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TOR signaling never gets old: aging, longevity and TORC1 activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

The TOR pathway comes of age

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Translational regulation mechanisms of AP-1 proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

NDRG2: a Myc-repressed gene involved in cancer and cell stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Amino acids and mTOR signalling in anabolic function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis

8 July 2018

1 reference

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Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant

8 July 2018

1 reference

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Life extension in the dwarf mouse

8 July 2018

1 reference

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The role of insulin and insulin-like growth factor-I in mammalian ageing

8 July 2018

1 reference

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Genetic mouse models of extended lifespan

8 July 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

8 July 2018

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

8 July 2018

1 reference

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Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family

8 July 2018

1 reference

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

8 July 2018

1 reference

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Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

8 July 2018

1 reference

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Cap43, a novel gene specifically induced by Ni2 compounds

8 July 2018

1 reference

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Crosstalk between mTOR complexes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Focus Issue: TOR Signaling, a Tale of Two Complexes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

From growing to secreting: new roles for mTOR in aging cells.

26 October 2018

1 reference

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Multi-faceted regulation of mitochondria by TOR.

26 October 2018

1 reference

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New insights into mTOR signaling: mTORC2 and beyond

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction

26 October 2018

1 reference

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Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma.

26 October 2018

1 reference

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Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Rheb activation of mTOR and S6K1 signaling

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Multiplex stress resistance in cells from long-lived dwarf mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

Gene expression profile of long-lived snell dwarf mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298324

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25456069

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25456069

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adipokines regulate systemic insulin sensitivity in accordance to existing energy reserves

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25456069

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1210/EN.2014-1690

1 reference

5 August 2017

1 reference

5 August 2017

1 reference