Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1. (Q34981676)

5 August 2017

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title

Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1. (English)

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5 August 2017

1

Birger Brodin

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5 August 2017

Carsten Uhd Nielsen

2

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5 August 2017

Bente Steffansen

series ordinal

3

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5 August 2017

Sven Frøkjaer

series ordinal

4

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5 August 2017

publication date

1 June 2002

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Basic and Clinical Pharmacology and Toxicology

5 August 2017

published in

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5 August 2017

volume

90

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5 August 2017

issue

6

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5 August 2017

page(s)

285-296

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Characteristics of transmural potential changes associated with the proton-peptide co-transport in toad small intestine.

5 August 2017

cites work

1 reference

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21 January 2018

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Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption

21 January 2018

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Electrophysiological analysis of the function of the mammalian renal peptide transporter expressed in xenopus laevis oocytes

21 January 2018

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Renal excretion of cephapirin and cephaloridine: Evidence for saturable tubular reabsorption

21 January 2018

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Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Distribution of peptide transporter PEPT2 mRNA in the rat nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Transport of amino acid aryl amides by the intestinal H /peptide cotransport system, PEPT1.

21 January 2018

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A micro-electrode study of oligopeptide absorption by the small intestinal epithelium of Necturus maculosus.

21 January 2018

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Expression and protein kinase C-dependent regulation of peptide/H co-transport system in the Caco-2 human colon carcinoma cell line

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Evidence for the Absolute Conformational Specificity of the Intestinal H /Peptide Symporter, PEPT1

21 January 2018

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Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Functional roles of histidine and tyrosine residues in the H( )-peptide transporter PepT1.

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Function and molecular structure of brush border membrane peptide/H symporters

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Expression and functional characterization of the mammalian intestinal peptide transporter PepT1 in the methylotropic yeast Pichia pastoris

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications

21 January 2018

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Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Glycyl-L-proline transport in rabbit enterocyte basolateral-membrane vesicles

21 January 2018

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https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

A peptide prodrug approach for improving bisphosphonate oral absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Expression cloning of a mammalian proton-coupled oligopeptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

sigma Receptor ligand-induced up-regulation of the H( )/peptide transporter PEPT1 in the human intestinal cell line Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Proton-coupled solute transport in the animal cell plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Dose-dependent absorption and elimination of cefadroxil in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Structural requirements for interaction with the oligopeptide transporter in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Mechanisms of glycyl-L-leucine uptake by guinea-pig small intestine: relative importance of intact-peptide transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Single-dose pharmacokinetics of valganciclovir in HIV- and CMV-seropositive subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

A novel inhibitor of the mammalian peptide transporter PEPT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Human intestinal H /peptide cotransporter. Cloning, functional expression, and chromosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

The human intestinal H /oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Structure and function of eukaryotic peptide transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Inhibition of the H /peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Cancer cell-targeted drug delivery utilizing oligopeptide transport activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Cellular and molecular mechanisms of dietary regulation on rat intestinal H /Peptide transporter PepT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Tubular localization and tissue distribution of peptide transporters in rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

The Predominant Contribution of Oligopeptide Transporter PepT1 to Intestinal Absorption of β-Lactam Antibiotics in the Rat Small Intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Metabolism, uptake, and transepithelial transport of the stereoisomers of Val-Val-Val in the human intestinal cell line, Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Peptide Mimics as Substrates for the Intestinal Peptide Transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Identification of the histidine residues involved in substrate recognition by a rat H /peptide cotransporter, PEPT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

An active mechanism for completion of the final stage of protein degradation in the liver, lysosomal transport of dipeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

H( )/solute-induced intracellular acidification leads to selective activation of apical Na( )/H( ) exchange in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Substrate upregulation of the human small intestinal peptide transporter, hPepT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Transepithelial transport properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Stereoselective uptake of beta-lactam antibiotics by the intestinal peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Characteristics of dipeptide transport in pig jejunum in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Intestinal peptide transport systems and oral drug availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

Evidence for active transport of the dipeptide glycylsarcosine by hamster jejunum in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Evidence for a glycyl-proline transport system in ovine enterocyte brush-border membrane vesicles

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Structural requirements for the intestinal mucosal-cell peptide transporter: the need for N-terminal alpha-amino group

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Decisive structural determinants for the interaction of proline derivatives with the intestinal H /peptide symporter

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H /peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Intestinal absorption of peptides peptide uptake by small intestine of Rana pipiens

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Functional separation of dipeptide transport and hydrolysis in kidney brush border membrane vesicles.

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Carrier-mediated uptake of cephalexin in human intestinal cells

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Molecular and Structural Features of the Proton-Coupled Oligopeptide Transporter Superfamily

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Intestinal absorption mechanism of dipeptide angiotensin converting enzyme inhibitors of the lysyl-proline type: lisinopril and SQ 29,852

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Enhancement of the small intestinal uptake of phenylalanyl-glycine via a H /oligopeptide transport system by chemical modification with fatty acids

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Passive and carrier-mediated intestinal absorption components of captopril

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditions

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Molecular modeling study of structural requirements for the oligopeptide transporter

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Intestinal absorption of peptides

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Suitability of enalapril as a probe of the dipeptide transporter system: in vitro and in vivo studies

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Cellular mechanisms in intestinal transfer of amino acids

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Expression of a cloned ovine gastrointestinal peptide transporter (oPepT1) in Xenopus oocytes induces uptake of oligopeptides in vitro

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Improved in vitro rheological system for studying the effect of fluid shear stress on cultured cells

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Molecular Determinants of Recognition for the Intestinal Peptide Carrier

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil–induced injury

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Functional expression of novel peptide transporter in renal basolateral membranes

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Mechanism of absorption of the dipeptide alpha-methyldopa-phe in intestinal brush-border membrane vesicles

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Intestinal absorption studies on peptide mimetic alpha-methyldopa prodrugs

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

Characterization of an oligopeptide transporter in renal lysosomes

1 reference

https://api.crossref.org/works/10.1034/J.1600-0773.2002.900601.X

7 January 2021

10.1034/J.1600-0773.2002.900601.X

Identifiers

DOI

1 reference

5 August 2017

1 reference