Assessing the potential of glucokinase activators in diabetes therapy (Q34976240)

5 August 2017

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title

Assessing the potential of glucokinase activators in diabetes therapy (English)

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5 August 2017

Franz M Matschinsky

1

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5 August 2017

publication date

17 April 2009

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Nature Reviews Drug Discovery

5 August 2017

published in

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5 August 2017

volume

8

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5 August 2017

issue

5

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5 August 2017

page(s)

399-416

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Allosteric activators of glucokinase: potential role in diabetes therapy

5 August 2017

cites work

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Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

31 March 2020

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The role of glucokinase in the phosphorylation of glucose by rat liver

31 March 2020

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Induced biosynthesis of liver glucokinase

31 March 2020

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Hormonal and dietary regulation of hepatic glucokinase

31 March 2020

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

31 March 2020

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Linkage of type 2 diabetes to the glucokinase gene

31 March 2020

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Genetic Disorders of the Pancreatic Beta Cell and Diabetes (Permanent Neonatal Diabetes and Maturity-Onset Diabetes of the Young)

31 March 2020

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Familial hyperinsulinism caused by an activating glucokinase mutation

31 March 2020

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The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy

31 March 2020

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Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations

31 March 2020

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Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation

31 March 2020

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Neonatal diabetes mellitus due to complete glucokinase deficiency

31 March 2020

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Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway

31 March 2020

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Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators

31 March 2020

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Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

31 March 2020

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An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism

31 March 2020

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A novel glucokinase activator modulates pancreatic islet and hepatocyte function

31 March 2020

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Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions

31 March 2020

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Glucokinase activators in diabetes management

31 March 2020

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Small molecule glucokinase activators as glucose lowering agents: a new paradigm for diabetes therapy

31 March 2020

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Evolution and regulatory role of the hexokinases

31 March 2020

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Mammalian glucokinase and its gene

31 March 2020

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Cell-specific roles of glucokinase in glucose homeostasis.

31 March 2020

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Molecular physiology of mammalian glucokinase

31 March 2020

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The mechanism by which rat liver glucokinase is inhibited by the regulatory protein

31 March 2020

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Competitive inhibition of liver glucokinase by its regulatory protein

31 March 2020

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Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation.

31 March 2020

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Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase

31 March 2020

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Glucokinase and molecular aspects of liver glycogen metabolism

31 March 2020

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Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin

31 March 2020

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The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation

31 March 2020

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The physiological role of glucokinase binding and translocation in hepatocytes

31 March 2020

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Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats

31 March 2020

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

31 March 2020

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

31 March 2020

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Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis

31 March 2020

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A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium

31 March 2020

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Conformational transition pathway in the allosteric process of human glucokinase

31 March 2020

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Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence

31 March 2020

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31 March 2020

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A glucose sensor role for glucokinase in anterior pituitary cells.

31 March 2020

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Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey

31 March 2020

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Glucokinase and glucose homeostasis: proven concepts and new ideas

31 March 2020

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

31 March 2020

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Neuronal glucosensing: what do we know after 50 years?

31 March 2020

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Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia

31 March 2020

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Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?

31 March 2020

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Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia

31 March 2020

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Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

31 March 2020

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Regulation of Glucose Metabolism in Pancreatic Islets

31 March 2020

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The glucokinase glucose sensor in human pancreatic islet tissue.

31 March 2020

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Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture

31 March 2020

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Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt

31 March 2020

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

31 March 2020

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Ca2 , cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

31 March 2020

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The AMP-activated protein kinase--fuel gauge of the mammalian cell?

31 March 2020

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Effects of glucose on insulin release and on intermediary metabolism of isolated perifused pancreatic islets from fed and fasted rats

31 March 2020

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Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

31 March 2020

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A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell

31 March 2020

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Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

31 March 2020

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Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas

31 March 2020

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Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats

31 March 2020

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Glucose and ATP levels in pancreatic islet tissue of normal and diabetic rats

31 March 2020

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Glucose and 3-0-Methylglucose Protection Against Alloxan Poisoning of Pancreatic Alpha and Beta Cells

31 March 2020

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Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity

31 March 2020

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Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.

31 March 2020

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Glucose sensing in L cells: a primary cell study

31 March 2020

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Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor

31 March 2020

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Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats

31 March 2020

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Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations

31 March 2020

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Genetic approaches to the molecular understanding of type 2 diabetes

31 March 2020

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Liver glucokinase: decreased activity in patients with type II diabetes

31 March 2020

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In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents

31 March 2020

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Glucokinase in B-cell-depleted islets of Langerhans.

31 March 2020

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Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects

31 March 2020

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Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii

31 March 2020

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Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young

31 March 2020

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From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation

31 March 2020

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Glucose modulation of glucokinase activation by small molecules

31 March 2020

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Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator

31 March 2020

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Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

31 March 2020

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The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

31 March 2020

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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

31 March 2020

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The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

31 March 2020

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

31 March 2020

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Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance

31 March 2020

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Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

31 March 2020

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Sulfonylurea receptors and mechanism of sulfonylurea action

31 March 2020

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Free fatty acid receptors and drug discovery

31 March 2020

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Glucokinase regulatory protein is associated with mitochondria in hepatocytes

31 March 2020

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Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes

31 March 2020

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Characterization of glucokinase regulatory protein-deficient mice

31 March 2020

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A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate

31 March 2020

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A novel glucokinase regulator in pancreatic beta cells: precursor of propionyl-CoA carboxylase beta subunit interacts with glucokinase and augments its activity

31 March 2020

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Regulation of β cell glucokinase by S-nitrosylation and association with nitric oxide synthase

31 March 2020

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Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation

31 March 2020

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Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer

31 March 2020

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Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony

31 March 2020

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Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation

31 March 2020

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Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

31 March 2020

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The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy

31 March 2020

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12 December 2020

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

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12 December 2020

Metabolism of glucose in the islets of Langerhans

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12 December 2020

Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion

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12 December 2020

SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.

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12 December 2020

Hormone secretion and glucose metabolism in islets of Langerhans of the isolated perfused pancreas from normal and streptozotocin diabetic rats

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12 December 2020

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

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12 December 2020

Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets

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12 December 2020

Differential regulation of glucokinase activity in pancreatic islets and liver of the rat

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12 December 2020

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

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12 December 2020

Signaling mechanisms during the response of pituitary gonadotropes to GnRH.

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12 December 2020

A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets

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12 December 2020

Glucose regulates glucokinase activity in cultured islets from rat pancreas

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12 December 2020

Demonstration of a slow conformational change in liver glucokinase by fluorescence spectroscopy

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12 December 2020

Targeting glucokinase activation for the treatment of type 2 diabetes--a status review.

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12 December 2020

Identifiers

DOI

10.1038/NRD2850

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5 August 2017

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