UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. (Q34953306)

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9 March 2020

title

UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations (English)

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9 March 2020

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5

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Ilaria Zanotti

7

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Silvia Rivara

10

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Marco Mor

11

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Alessio Lodola

12

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Massimiliano Tognolini

13

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author name string

I Hassan-Mohamed

1

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C Giorgio

2

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M Incerti

3

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S Russo

4

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E B Pasquale

6

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P Vicini

8

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E Barocelli

9

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language of work or name

English

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publication date

28 August 2014

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British Journal of Pharmacology

9 March 2020

published in

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volume

171

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issue

23

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page(s)

5195-5208

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The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors

9 March 2020

cites work

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Target hopping as a useful tool for the identification of novel EphA2 protein-protein antagonists.

8 July 2018

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Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

8 July 2018

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HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery

8 July 2018

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The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.

8 July 2018

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EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

8 July 2018

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A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.

8 July 2018

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Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid.

8 July 2018

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Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols

8 July 2018

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Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor

8 July 2018

1 reference

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Perturbation of the EphA2-EphrinA1 system in human prostate cancer cells by colonic (poly)phenol catabolites.

8 July 2018

1 reference

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Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase

8 July 2018

1 reference

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Targeting Eph receptors with peptides and small molecules: progress and challenges

8 July 2018

1 reference

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A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors

8 July 2018

1 reference

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Polyphenol rich botanicals used as food supplements interfere with EphA2-ephrinA1 system.

8 July 2018

1 reference

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Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation

8 July 2018

1 reference

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Emerging strategies for EphA2 receptor targeting for cancer therapeutics

8 July 2018

1 reference

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Biomarkers to predict the clinical efficacy of bevacizumab in cancer

8 July 2018

1 reference

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EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

8 July 2018

1 reference

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The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

8 July 2018

1 reference

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Architecture of Eph receptor clusters

8 July 2018

1 reference

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Eph receptors and ephrins in cancer: bidirectional signalling and beyond

8 July 2018

1 reference

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

8 July 2018

1 reference

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Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

8 July 2018

1 reference

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

8 July 2018

1 reference

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Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling

8 July 2018

1 reference

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Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

8 July 2018

1 reference

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MM-GB/SA rescoring of docking poses in structure-based lead optimization.

8 July 2018

1 reference

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EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets

8 July 2018

1 reference

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Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity

8 July 2018

1 reference

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Mechanisms of drug inhibition of signalling molecules

8 July 2018

1 reference

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Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression

8 July 2018

1 reference

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Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy

8 July 2018

1 reference

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Eph receptor signalling casts a wide net on cell behaviour

8 July 2018

1 reference

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Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling

8 July 2018

1 reference

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Some quantitative uses of drug antagonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294034

Contact-dependent signaling during the late events of platelet activation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294034

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294034

The Eph family of receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294034

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

8 July 2018

1 reference

Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis

21 January 2018

1 reference

Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4).

21 January 2018

1 reference

Eph receptors and ephrins restrict cell intermingling and communication

21 January 2018

1 reference

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

21 January 2018

1 reference

In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/BPH.12669

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24597515 AND SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24597515 AND SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

24597515

1 reference