Structural effects of quinacrine binding in the open channel of the acetylcholine receptor. (Q34918704)

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1 November 2019

title

Structural effects of quinacrine binding in the open channel of the acetylcholine receptor (English)

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1 November 2019

2

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1 November 2019

author name string

Yong Yu

series ordinal

1

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1 November 2019

Arthur Karlin

series ordinal

3

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1 November 2019

language of work or name

English

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publication date

18 March 2003

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Proceedings of the National Academy of Sciences of the United States of America

1 November 2019

published in

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1 November 2019

volume

100

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1 November 2019

issue

7

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1 November 2019

page(s)

3907-3912

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Emerging structure of the nicotinic acetylcholine receptors

1 November 2019

cites work

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

8 July 2018

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Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

8 July 2018

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Modeling of loops in protein structures

8 July 2018

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Nicotinic receptors at the amino acid level

8 July 2018

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Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel

8 July 2018

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Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism

8 July 2018

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The location of the gate in the acetylcholine receptor channel

8 July 2018

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Contribution of the beta subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor

8 July 2018

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State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

8 July 2018

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Kinked-Helices Model of the Nicotinic Acetylcholine Receptor Ion Channel and Its Complexes with Blockers: Simulation by the Monte Carlo Minimization Method

8 July 2018

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Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the β-Subunit

8 July 2018

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Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

8 July 2018

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End-plate channel opening and the kinetics of quinacrine (mepacrine) block

8 July 2018

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The permeability of the endplate channel to organic cations in frog muscle

8 July 2018

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Time-resolved photolabeling by quinacrine azide of a noncompetitive inhibitor site of the nicotinic acetylcholine receptor in a transient, agonist-induced state.

8 July 2018

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Explorations of the nicotinic acetylcholine receptor

8 July 2018

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Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor

8 July 2018

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Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

8 July 2018

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A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor

8 July 2018

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The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel

8 July 2018

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An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

8 July 2018

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Tris /Na permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region

8 July 2018

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Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262

8 July 2018

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Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations

8 July 2018

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Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe

8 July 2018

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Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells

8 July 2018

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Acetylcholine receptor binding properties and ion permeability response after covalent attachment of the local anaesthetic quinacrine

8 July 2018

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Mode of action of quinacrine on the acetylcholine receptor ionic channel complex

8 July 2018

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Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

8 July 2018

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Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

21 January 2018

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Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit

21 January 2018

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Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit

21 January 2018

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Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall

21 January 2018

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Mutations in the M1 region of the nicotinic acetylcholine receptor alter the sensitivity to inhibition by quinacrine

21 January 2018

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Quinacrine noncompetitive inhibitor binding site localized on the Torpedo acetylcholine receptor in the open state

21 January 2018

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The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics

21 January 2018

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Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel

21 January 2018

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Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel

21 January 2018

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Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.

26 October 2018

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Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

26 October 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0730718100

Acetylcholine receptor channel imaged in the open state

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0730718100

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0730718100

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

21 January 2018

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Azidoacridines as photoaffinity probes for ionic channels in excitable membranes

21 January 2018

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Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

21 January 2018

1 reference

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Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

21 January 2018

1 reference

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Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

21 January 2018

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Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from torpedo marmorata

21 January 2018

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Asymmetry of the rat acetylcholine receptor subunits in the narrow region of the pore

21 January 2018

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Reaction of quinacrine mustard with the acetylcholine receptor from Torpedo californica

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12644710

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]acetylcholine binding and sodium-22 ion fluxes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12644710

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0730718100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12644710 AND SRC:MED&resulttype=core&format=json

1 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12644710 AND SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

12644710

1 reference