The PTEN-PI3K pathway: of feedbacks and cross-talks (Q34828662)

4 August 2017

title

The PTEN-PI3K pathway: of feedbacks and cross-talks (English)

1 reference

4 August 2017

A Carracedo

1

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4 August 2017

P P Pandolfi

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 September 2008

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4 August 2017

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4 August 2017

volume

27

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4 August 2017

issue

41

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4 August 2017

page(s)

5527-5541

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The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.

4 August 2017

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Oncogenic signaling of class I PI3K isoforms

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A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth

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Impaired Fas response and autoimmunity in Pten /- mice

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Pten is essential for embryonic development and tumour suppression

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PTEN: one gene, many syndromes

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

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Current development of mTOR inhibitors as anticancer agents

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Robust neuronal symmetry breaking by Ras-triggered local positive feedback

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Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

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Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

31 March 2020

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

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Defective STAT signaling by the leptin receptor in diabetic mice

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Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

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Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

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Defining the role of mTOR in cancer

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PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

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PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma

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Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

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c-Jun promotes cellular survival by suppression of PTEN.

31 March 2020

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The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

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Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Possible mechanisms of disease development in tuberous sclerosis

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Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

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Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

31 March 2020

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Prevalence of a polymorphism of the phosphatidylinositol 3-kinase p85 alpha regulatory subunit (codon 326 Met-->Ile) in Japanese NIDDM patients

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Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

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Direct control of the Forkhead transcription factor AFX by protein kinase B

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN /- mice by the p85 regulatory subunits of phosphoinositide 3-kinase

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31 March 2020

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Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

31 March 2020

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Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer

31 March 2020

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Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

31 March 2020

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

31 March 2020

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

31 March 2020

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Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung

31 March 2020

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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AKT/PKB signaling: navigating downstream

31 March 2020

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

31 March 2020

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

1 reference

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Regulation of Raf-Akt Cross-talk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2008.247

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2008.247

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2008.247

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2008.247

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2008.247

The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Akt regulates growth by directly phosphorylating Tsc2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Tenets of PTEN tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Heterotrimeric G-protein betagamma-dimers in growth and differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Negative regulation of the forkhead transcription factor FKHR by Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Identification of a tumour suppressor network opposing nuclear Akt function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Ubiquitination regulates PTEN nuclear import and tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Suppression of PTEN expression by NF-kappa B prevents apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphoinositide 3-kinase-dependent activation of Rac.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Functional inhibition of PI3K by the betaGBP molecule suppresses Ras-MAPK signalling to block cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Muscle-specific Pten deletion protects against insulin resistance and diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

PI3K pathway alterations in cancer: variations on a theme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Class I PI3K in oncogenic cellular transformation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

Phosphorylation and regulation of Raf by Akt (protein kinase B)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.247

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.247

1 reference

Dimensions Publication ID

4 August 2017

1040854906

0 references

1 reference