The impact of enzyme engineering upon natural product glycodiversification (Q34803952)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18678278 AND SRC:MED&resulttype=core&format=json

11 January 2020

review article

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title

The impact of enzyme engineering upon natural product glycodiversification (English)

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11 January 2020

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11 January 2020

author name string

Gavin J Williams

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1

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11 January 2020

Richard W Gantt

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2

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11 January 2020

publication date

1 October 2008

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Current Opinion in Chemical Biology

11 January 2020

published in

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11 January 2020

volume

12

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11 January 2020

issue

5

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11 January 2020

page(s)

556-564

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Natural product glycosyltransferases: properties and applications

11 January 2020

cites work

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Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis

8 July 2018

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Sweet antibiotics - the role of glycosidic residues in antibiotic and antitumor activity and their randomization

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Natural products to drugs: natural product-derived compounds in clinical trials

8 July 2018

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Site-specific linking of biomolecules via glycan residues using glycosyltransferases

8 July 2018

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Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization

8 July 2018

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A high-throughput pH indicator assay for screening glycosyltransferase saturation mutagenesis libraries

8 July 2018

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Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

8 July 2018

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A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay

8 July 2018

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A kinetic analysis of regiospecific glucosylation by two glycosyltransferases of Arabidopsis thaliana: domain swapping to introduce new activities

8 July 2018

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A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution

8 July 2018

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Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines

8 July 2018

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Applications of glycosyltransferases in the site-specific conjugation of biomolecules and the development of a targeted drug delivery system and contrast agents for MRI.

8 July 2018

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Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.

8 July 2018

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Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

8 July 2018

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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution

8 July 2018

1 reference

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Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin

8 July 2018

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Unusual sugar biosynthesis and natural product glycodiversification

8 July 2018

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Enhancing the latent nucleotide triphosphate flexibility of the glucose-1-phosphate thymidylyltransferase RmlA.

8 July 2018

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Engineering the glycosylation of natural products in actinomycetes

8 July 2018

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The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

8 July 2018

1 reference

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Natural products as sources of new drugs over the last 25 years

8 July 2018

1 reference

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Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli

8 July 2018

1 reference

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The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification

8 July 2018

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The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility

8 July 2018

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Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4.

8 July 2018

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Colchicine glycorandomization influences cytotoxicity and mechanism of action

8 July 2018

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De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation

8 July 2018

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Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

8 July 2018

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Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

8 July 2018

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High-throughput screening methodology for the directed evolution of glycosyltransferases

8 July 2018

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Enzymatic tools for engineering natural product glycosylation.

8 July 2018

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Enabling glycosyltransferase evolution: a facile substrate-attachment strategy for phage-display enzyme evolution

8 July 2018

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Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification

8 July 2018

1 reference

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

8 July 2018

1 reference

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Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization

8 July 2018

1 reference

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Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC.

8 July 2018

1 reference

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Diversifying vancomycin via chemoenzymatic strategies.

8 July 2018

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Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

8 July 2018

1 reference

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Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands

8 July 2018

1 reference

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Creation of the first anomeric d / l -sugar kinase by means of directed evolution

8 July 2018

1 reference

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Antibiotic optimization via in vitro glycorandomization

8 July 2018

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Remarkable structural similarities between diverse glycosyltransferases

8 July 2018

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Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

8 July 2018

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Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity

8 July 2018

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Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.

8 July 2018

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Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization

8 July 2018

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The role of carbohydrates in biologically active natural products

8 July 2018

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Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates

8 July 2018

1 reference

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Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substrates

26 October 2018

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Selective detection of sugar phosphates by capillary electrophoresis/mass spectrometry and its application to an engineered E. coli host

26 October 2018

1 reference

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De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction

26 October 2018

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De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin

26 October 2018

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Characterization and engineering of glycosyltransferases responsible for steroid saponin biosynthesis in Solanaceous plants

26 October 2018

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Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

26 October 2018

1 reference

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Strategies for the chemoenzymatic synthesis of deoxysugar nucleotides: substrate binding versus catalysis

26 October 2018

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Unusually broad substrate tolerance of a heat-stable archaeal sugar nucleotidyltransferase for the synthesis of sugar nucleotides

26 October 2018

1 reference

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Alteration of sugar donor specificities of plant glycosyltransferases by a single point mutation

26 October 2018

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Structure-based enhancement of the first anomeric glucokinase

26 October 2018

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Directed evolution of an amine oxidase possessing both broad substrate specificity and high enantioselectivity

26 October 2018

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Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

26 October 2018

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Probing the Breadth of Macrolide Glycosyltransferases: In Vitro Remodeling of a Polyketide Antibiotic Creates Active Bacterial Uptake and Enhances Potency

26 October 2018

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Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (iso)flavonoid glycosylation

9 December 2018

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12 December 2020

Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin

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12 December 2020

Model for antibiotic optimization via neoglycosylation: synthesis of liponeoglycopeptides active against VRE

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12 December 2020

Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization

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12 December 2020

Enzyme-catalyzed synthesis of furanosyl nucleotides

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12 December 2020

Exploiting nucleotidylyltransferases to prepare sugar nucleotides

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12 December 2020

Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins

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12 December 2020

10.1016/J.CBPA.2008.07.013

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18678278 AND SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18678278 AND SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

18678278

1 reference