Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. (Q34786164)

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3 March 2020

title

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules (English)

1 reference

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3 March 2020

1 reference

8

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3 March 2020

Wei Zheng

11

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3 March 2020

Ewa Stepniak-Konieczna

2

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3 March 2020

Jason Hoskins

7

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13

George C Schatz

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3 March 2020

9

Juan J Marugan

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3 March 2020

10

Samarjit Patnaik

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3 March 2020

16

Matthew D Disney

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3 March 2020

14

Krzysztof Sobczak

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3 March 2020

author name string

Jessica L Childs-Disney

1

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3 March 2020

Tuan Tran

3

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3 March 2020

Ilyas Yildirim

4

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3 March 2020

HaJeung Park

5

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3 March 2020

Catherine Z Chen

6

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3 March 2020

Chris P Austin

12

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3 March 2020

Charles A Thornton

15

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language of work or name

English

0 references

publication date

1 January 2013

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3 March 2020

published in

Nature Communications

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3 March 2020

volume

4

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3 March 2020

page(s)

2044

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RNA splicing is responsive to MBNL1 dose

3 March 2020

cites work

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Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins

8 July 2018

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Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy

8 July 2018

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Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive

8 July 2018

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Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching

8 July 2018

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Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts

8 July 2018

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Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

8 July 2018

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Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

8 July 2018

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CAG repeats mimic CUG repeats in the misregulation of alternative splicing

8 July 2018

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Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

8 July 2018

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Alternative splicing dysregulation secondary to skeletal muscle regeneration

8 July 2018

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8 July 2018

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NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.

8 July 2018

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The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

8 July 2018

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Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

8 July 2018

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8 July 2018

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Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.

8 July 2018

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Pentamidine reverses the splicing defects associated with myotonic dystrophy.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing

8 July 2018

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Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy

8 July 2018

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Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

8 July 2018

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8 July 2018

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8 July 2018

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26 October 2018

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26 October 2018

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9 December 2018

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12 December 2020

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12 December 2020

Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons

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Identifiers

DOI

10.1038/NCOMMS3044

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23806903 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 March 2020

ADS bibcode

2013NatCo...4.2044C

0 references

0 references

1 reference

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3 March 2020

PubMed publication ID

23806903

1 reference

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