The tumour suppressor RASSF1A is a novel substrate of PKC. (Q34783040)

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8 January 2020

title

The tumour suppressor RASSF1A is a novel substrate of PKC (English)

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Peter Joseph Jacques Parker

8 January 2020

author

series ordinal

3

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8 January 2020

author name string

Sunil K Verma

series ordinal

1

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8 January 2020

Trivadi S Ganesan

series ordinal

2

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8 January 2020

language of work or name

English

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publication date

2 June 2008

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8 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18514071 AND SRC:MED&resulttype=core&format=json

8 January 2020

volume

582

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8 January 2020

issue

15

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8 January 2020

page(s)

2270-2276

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Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene

8 January 2020

cites work

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Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis

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Control of microtubule stability by the RASSF1A tumor suppressor

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RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

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Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest

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The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation

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Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form

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The bisindolylmaleimide GF 109203X, a selective inhibitor of protein kinase C, does not inhibit the potentiating effect of phorbol ester on ethanol-induced phospholipase C-mediated hydrolysis of phosphatidylethanolamine

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PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters

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Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.

21 January 2018

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Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation

21 January 2018

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Centrosome and cell division

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