Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation (Q34768753)

4 August 2017

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title

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation (English)

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stem cell differentiation

4 August 2017

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Kenneth S Zaret

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4 August 2017

publication date

1 May 2008

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4 August 2017

published in

Nature Reviews Genetics

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4 August 2017

volume

9

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4 August 2017

issue

5

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4 August 2017

page(s)

329-340

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Retinoic acid signaling and the evolution of chordates

4 August 2017

cites work

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Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1.

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Gene regulatory factors in pancreatic development

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Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

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Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

31 March 2020

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Initiation of mammalian liver development from endoderm by fibroblast growth factors

31 March 2020

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Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors

31 March 2020

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Insulin-promoter-factor 1 is required for pancreas development in mice

31 March 2020

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Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

31 March 2020

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Notch signalling controls pancreatic cell differentiation

31 March 2020

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Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas

31 March 2020

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Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development

31 March 2020

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Control of endodermal endocrine development by Hes-1

31 March 2020

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Notch signaling controls multiple steps of pancreatic differentiation

31 March 2020

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Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice

31 March 2020

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Lack of TCF2/vHNF1 in mice leads to pancreas agenesis

31 March 2020

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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

31 March 2020

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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

31 March 2020

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The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

31 March 2020

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Development of the mammalian liver and ventral pancreas is dependent on GATA4.

31 March 2020

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Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3

31 March 2020

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The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade

31 March 2020

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Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues.

31 March 2020

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Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages

31 March 2020

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Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver

31 March 2020

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Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver.

31 March 2020

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Isolation of hepatoblasts based on the expression of Dlk/Pref-1

31 March 2020

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Cell-autonomous and signal-dependent expression of liver and intestine marker genes in pluripotent precursor cells from Xenopus embryos

31 March 2020

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Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm

31 March 2020

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Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung

31 March 2020

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Bmp and Fgf signaling are essential for liver specification in zebrafish.

31 March 2020

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Regulation of Hex gene expression and initial stages of avian hepatogenesis by Bmp and Fgf signaling.

31 March 2020

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An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.

31 March 2020

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BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm

31 March 2020

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Direct hepatic fate specification from mouse embryonic stem cells

31 March 2020

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Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

31 March 2020

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The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

31 March 2020

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

31 March 2020

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

31 March 2020

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A genome-wide association study identifies novel risk loci for type 2 diabetes

31 March 2020

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

31 March 2020

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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

31 March 2020

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Generation of insulin-producing islet-like clusters from human embryonic stem cells.

31 March 2020

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Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system

31 March 2020

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Directed differentiation of human embryonic stem cells into functional hepatic cells

31 March 2020

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Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme

31 March 2020

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An endothelial-mesenchymal relay pathway regulates early phases of pancreas development

31 March 2020

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Induction of pancreatic differentiation by signals from blood vessels.

31 March 2020

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Liver organogenesis promoted by endothelial cells prior to vascular function.

31 March 2020

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Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.

31 March 2020

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Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development

31 March 2020

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Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells

31 March 2020

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Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus

31 March 2020

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Hedgehog signaling in pancreas development

31 March 2020

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Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms

31 March 2020

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Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice

31 March 2020

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Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development

31 March 2020

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Mesodermal Wnt2b signalling positively regulates liver specification.

31 March 2020

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Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation

31 March 2020

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Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification

31 March 2020

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Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration

31 March 2020

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The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development.

31 March 2020

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Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus.

31 March 2020

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Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development

31 March 2020

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Zebrafish hhex regulates liver development and digestive organ chirality

31 March 2020

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Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells

31 March 2020

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Gene regulatory networks and the evolution of animal body plans

31 March 2020

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Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins

31 March 2020

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The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

31 March 2020

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HNF-3 beta is essential for node and notochord formation in mouse development

31 March 2020

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The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo

31 March 2020

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Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

31 March 2020

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GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo

31 March 2020

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Foxa2 is required for the differentiation of pancreatic alpha-cells

31 March 2020

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GATA6 is essential for embryonic development of the liver but dispensable for early heart formation

31 March 2020

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Gata4 regulates the formation of multiple organs.

31 March 2020

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Fgf10 regulates hepatopancreatic ductal system patterning and differentiation.

31 March 2020

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Polycomb silencing mechanisms and the management of genomic programmes

31 March 2020

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Control of pancreas and liver gene expression by HNF transcription factors

31 March 2020

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Plasticity and expanding complexity of the hepatic transcription factor network during liver development

31 March 2020

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

31 March 2020

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Growth and regeneration of adult beta cells does not involve specialized progenitors.

31 March 2020

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The role of hepatocytes and oval cells in liver regeneration and repopulation

31 March 2020

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Liver regeneration: from myth to mechanism

31 March 2020

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New sources of pancreatic beta-cells

31 March 2020

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Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

31 March 2020

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Metaplasia and transdifferentiation: from pure biology to the clinic

31 March 2020

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Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver

31 March 2020

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Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice

31 March 2020

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Bone marrow as a potential source of hepatic oval cells

31 March 2020

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Pluripotency of mesenchymal stem cells derived from adult marrow

31 March 2020

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Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

31 March 2020

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Cell fusion is the principal source of bone-marrow-derived hepatocytes

31 March 2020

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Myelomonocytic cells are sufficient for therapeutic cell fusion in liver

31 March 2020

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

31 March 2020

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On the origin of pancreatic endocrine cells

31 March 2020

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Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development.

31 March 2020

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Molecular basis of transdifferentiation of pancreas to liver

31 March 2020

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Experimental conversion of liver to pancreas

31 March 2020

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Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas

31 March 2020

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NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

31 March 2020

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Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells.

31 March 2020

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Opposing actions of Arx and Pax4 in endocrine pancreas development

31 March 2020

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Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

31 March 2020

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

31 March 2020

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Induced pluripotent stem cell lines derived from human somatic cells

31 March 2020

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Single-cell transcript analysis of pancreas development.

31 March 2020

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PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

31 March 2020

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Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

31 March 2020

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Signalling downstream of activated mammalian Notch

31 March 2020

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Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue

31 March 2020

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Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation.

31 March 2020

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The mouse bagpipe gene controls development of axial skeleton, skull, and spleen

31 March 2020

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Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice

31 March 2020

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Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

31 March 2020

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Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

31 March 2020

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All beta cells contribute equally to islet growth and maintenance

31 March 2020

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Intrinsic regulators of pancreatic beta-cell proliferation

31 March 2020

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Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1

31 March 2020

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Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition

31 March 2020

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The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle

31 March 2020

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Elucidation of a universal size-control mechanism in Drosophila and mammals

31 March 2020

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Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

31 March 2020

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Formation of the digestive system in zebrafish. II. Pancreas morphogenesis.

31 March 2020

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Origin of the zebrafish endocrine and exocrine pancreas

31 March 2020

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A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease

31 March 2020

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Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria

31 March 2020

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Genetic control of the cell-division cycle in yeast. I. Detection of mutants

31 March 2020

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Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4

31 March 2020

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Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

31 March 2020

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Genome-wide mapping of in vivo protein-DNA interactions

31 March 2020

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

31 March 2020

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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG2318

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Dimensions Publication ID

4 August 2017

1040463390

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