Chronic myelogenous leukemia: mechanisms underlying disease progression. (Q34765301)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12145676 AND SRC:MED&resulttype=core&format=json

11 November 2019

review article

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title

Chronic myelogenous leukemia: mechanisms underlying disease progression (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12145676 AND SRC:MED&resulttype=core&format=json

11 November 2019

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3

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11 November 2019

Arun S Shet

series ordinal

1

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11 November 2019

author name string

Jahagirdar BN

series ordinal

2

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11 November 2019

publication date

1 August 2002

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11 November 2019

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11 November 2019

volume

16

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11 November 2019

issue

8

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11 November 2019

page(s)

1402-1411

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Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period

11 November 2019

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

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Acute leukaemia in bcr/abl transgenic mice

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Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice

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In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

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Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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The BCR/ABL hybrid gene

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The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene

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Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

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The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

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Abl tyrosine protein kinase

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Abl tyrosine kinase in signal transduction and cell-cycle regulation

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Dominant negative MYC blocks transformation by ABL oncogenes

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

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7 January 2021

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

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7 January 2021

Regulation of cell death by the Abl tyrosine kinase

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Integrins regulate the association and phosphorylation of paxillin by c-Abl

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7 January 2021

The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19

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7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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7 January 2021

Increased neutrophil respiratory burst in bcr-null mutants

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7 January 2021

Biology of chronic myelogenous leukemia

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7 January 2021

Molecular consequences of the BCR-ABL translocation in chronic myelogenous leukemia

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7 January 2021

The biology of chronic myeloid leukemia

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7 January 2021

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

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7 January 2021

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

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7 January 2021

SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence

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7 January 2021

Bcr phosphorylated on tyrosine 177 binds Grb2

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7 January 2021

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene

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7 January 2021

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway

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7 January 2021

Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family

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7 January 2021

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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7 January 2021

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

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7 January 2021

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

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7 January 2021

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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7 January 2021

Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

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7 January 2021

PI3K: downstream AKTion blocks apoptosis

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7 January 2021

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

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STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

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Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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7 January 2021

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity

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7 January 2021

BCR/ABL induces multiple abnormalities of cytoskeletal function

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7 January 2021

Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL

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7 January 2021

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

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7 January 2021

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

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7 January 2021

Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis

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7 January 2021

Primary proliferating immature myeloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal

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7 January 2021

Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids

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7 January 2021

BCR-ABL: an anti-apoptosis gene in chronic myelogenous leukemia.

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7 January 2021

A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

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7 January 2021

Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras.

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7 January 2021

Apoptosis in chronic myelogenous leukemia: studies of stage-specific differences.

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

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7 January 2021

BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

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7 January 2021

Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation

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7 January 2021

CML: mechanisms of disease initiation and progression

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7 January 2021

Cell biology of CML cells

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7 January 2021

The control of hematopoiesis and leukemia: from basic biology to the clinic

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7 January 2021

Effect of differentiation-inducing agents on oncogene expression in a chronic myelogenous leukemia cell line

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7 January 2021

Chronic myeloid leukemia as an immunological target

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7 January 2021

The role of FAS-mediated apoptosis in chronic myelogenous leukemia

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7 January 2021

Fas ligand is highly expressed in acute leukemia and during the transformation of chronic myeloid leukemia to blast crisis.

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7 January 2021

The Role of Autologous Natural Killer Cells in Chronic Myelogenous Leukemia

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7 January 2021

Sensitivity to the abl inhibitor STI571 in fresh leukaemic cells obtained from chronic myelogenous leukaemia patients in different stages of disease

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7 January 2021

Studies of some mechanisms of drug resistance in chronic myeloid leukemia (CML)

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7 January 2021

Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL( ) leukemic cells to the abl inhibitor STI571

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7 January 2021

The cytogenetic scenario of chronic myeloid leukemia

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7 January 2021

Karyotype abnormalities and their clinical significance in blast crisis of chronic myeloid leukemia

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7 January 2021

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia

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7 January 2021

p53 loss and point mutations are associated with suppression of apoptosis and progression of CML into myeloid blastic crisis.

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7 January 2021

Detection of c-myc oncogene amplification in a CML blastic phase patient with double minute chromosomes.

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7 January 2021

Studies of proto-oncogene expression in the chronic and blastic phases of chronic myelogenous leukemia.

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7 January 2021

Transforming genes in chronic myelogenous leukemia

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7 January 2021

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

1 reference

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7 January 2021

Karyotypic changes during the course of blastic crisis of chronic myelogenous leukemia

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7 January 2021

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

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7 January 2021

A novel form of Epstein-Barr virus latency in normal B cells in vivo

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7 January 2021

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

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7 January 2021

Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest

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7 January 2021

p53, the cellular gatekeeper for growth and division

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https://api.crossref.org/works/10.1038/SJ.LEU.2402577

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1038/SJ.LEU.2402577

7 January 2021

Role of p53 in leukemogenesis of chronic myeloid leukemia

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7 January 2021

A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation

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7 January 2021

The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia

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7 January 2021

Blast crisis of Ph-positive chronic myeloid leukemia with isochromosome 17q: report of 12 cases and review of the literature

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7 January 2021

Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase.

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7 January 2021

Biphenotypic Blast Crisis of Chronic Myelogenous Leukemia: Abnormalities of p53 and Retinoblastoma Genes

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7 January 2021

Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia.

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7 January 2021

p16ink4a gene and hematological malignancies.

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7 January 2021

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells

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7 January 2021

Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia

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7 January 2021

Significance of cytogenetic clonal evolution in chronic myelogenous leukemia

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7 January 2021

Differential complementation of Bcr-Abl point mutants with c-Myc

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7 January 2021

Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo

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7 January 2021

bcl-2 and c-myc Expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase

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7 January 2021

Identification of several genes differentially expressed during progression of chronic myelogenous leukemia.

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7 January 2021

c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells

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7 January 2021

Molecular characteristics of chronic myelogenous leukemia in blast crisis

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7 January 2021

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

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7 January 2021

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

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7 January 2021

Absence of microsatellite instability during the progression of chronic myelocytic leukemia

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7 January 2021

p53 Mutations, Methylation and Genomic Instability in the Progression of Chronic Myeloid Leukaemia

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7 January 2021

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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7 January 2021

BCR-ABL down-regulates the DNA repair protein DNA-PKcs

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7 January 2021

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402577

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12145676 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 November 2019

1030621906

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1 reference