Chemokine receptor antagonism as an approach to anti-inflammatory therapy: 'just right' or plain wrong? (Q34754683)

4 August 2017

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title

Chemokine receptor antagonism as an approach to anti-inflammatory therapy: 'just right' or plain wrong? (English)

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4 August 2017

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Percy H Carter

1

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4 August 2017

publication date

1 August 2002

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Current Opinion in Chemical Biology

4 August 2017

published in

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4 August 2017

volume

6

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4 August 2017

issue

4

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4 August 2017

page(s)

510-525

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Chemokines: immunology's high impact factors

4 August 2017

cites work

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CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

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Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome

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New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice

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Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent

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Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection

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A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection

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A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation

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7 January 2021

Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor

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7 January 2021

CCR5 Δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis

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7 January 2021

Delta 32 deletion of CCR5 gene and association with asthma or atopy

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7 January 2021

Delta 32 mutation of the chemokine-receptor 5 gene in inflammatory bowel disease

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CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis.

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7 January 2021

Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion

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7 January 2021

Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine

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7 January 2021

Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection

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7 January 2021

Generation and analysis of mice lacking the chemokine fractalkine

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7 January 2021

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

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7 January 2021

A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection

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7 January 2021

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

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7 January 2021

Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis

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7 January 2021

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

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7 January 2021

A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation

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7 January 2021

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

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7 January 2021

CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo

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7 January 2021

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

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7 January 2021

Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease

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7 January 2021

Variant eotaxin: its effects on the asthma phenotype

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7 January 2021

Rules of chemokine receptor association with T cell polarization in vivo

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7 January 2021

The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics

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7 January 2021

Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection

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7 January 2021

Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection

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7 January 2021

Requirement of the chemokine receptor CXCR3 for acute allograft rejection

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7 January 2021

CXCL10 (IFN-gamma-inducible protein-10) control of encephalitogenic CD4 T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis.

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7 January 2021

Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis

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7 January 2021

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

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7 January 2021

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo

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7 January 2021

Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential

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7 January 2021

Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo

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7 January 2021

Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation

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7 January 2021

Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses.

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7 January 2021

Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis

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7 January 2021

The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice

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7 January 2021

Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1 lymphocyte-associated Th2-type immune response in the inte

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7 January 2021

Protection from pulmonary fibrosis in the absence of CCR2 signaling

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7 January 2021

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

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7 January 2021

Safe use of the CXCR4 inhibitor ALX40-4C in humans

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7 January 2021

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

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7 January 2021

Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4

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7 January 2021

Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.

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7 January 2021

CC chemokine receptor 4 expression on peripheral blood CD4 T cells reflects disease activity of atopic dermatitis

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7 January 2021

Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice

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7 January 2021

A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

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7 January 2021

Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

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7 January 2021

Chemokines and the tissue-specific migration of lymphocytes

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7 January 2021

CCL27-CCR10 interactions regulate T cell-mediated skin inflammation

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7 January 2021

CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin

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7 January 2021

CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.

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7 January 2021

Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic Subjects

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7 January 2021

Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors.

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7 January 2021

Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis.

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7 January 2021

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

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7 January 2021

CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.

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7 January 2021

Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation

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7 January 2021

In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

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7 January 2021

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

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7 January 2021

Subspecialization of CXCR5 T cells: B helper activity is focused in a germinal center-localized subset of CXCR5 T cells

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7 January 2021

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

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7 January 2021

Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection

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7 January 2021

Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.

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7 January 2021

Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus.

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7 January 2021

A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses.

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7 January 2021

Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis

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7 January 2021

Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice

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7 January 2021

Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice

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7 January 2021

Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).

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7 January 2021

CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness

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7 January 2021

Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia

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7 January 2021

Chemokines as regulators of T cell differentiation.

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7 January 2021

The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3

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7 January 2021

Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1

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7 January 2021

Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease

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7 January 2021

Differential roles of CC chemokine ligand 2/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity

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7 January 2021

Nicotinamide N-oxides as CXCR2 antagonists

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7 January 2021

Discovery of novel non-peptide CCR1 receptor antagonists

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7 January 2021

Design, synthesis, and discovery of a novel CCR1 antagonist

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7 January 2021

Discovery of a novel CCR3 selective antagonist

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7 January 2021

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships

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7 January 2021

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.

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7 January 2021

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists

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7 January 2021

Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection

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7 January 2021

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

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7 January 2021

Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

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7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

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7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes

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7 January 2021

CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

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7 January 2021

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity

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7 January 2021

Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection

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7 January 2021

Monomeric solution structure of the prototypical 'C' chemokine lymphotactin

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7 January 2021

Structural comparison of monomeric variants of the chemokine MIP-1beta having differing ability to bind the receptor CCR5

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7 January 2021

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

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7 January 2021

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

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7 January 2021

Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine.

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7 January 2021

Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

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7 January 2021

Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.

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7 January 2021

N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities

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7 January 2021

Identification of receptor binding and activation determinants in the N-terminal and N-loop regions of the CC chemokine eotaxin

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7 January 2021

Mutagenesis studies of interleukin-8. Identification of a second epitope involved in receptor binding

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https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Structural determinants of CCR5 recognition and HIV-1 blockade in RANTES.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1. Receptor activation by a pseudo-tethered ligand

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Structure and function of G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: implications for development of selective CXCR4 antagonists

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

A double-blind placebo-controlled study of an infusion of lexipafant (Platelet-activating factor receptor antagonist) in patients with severe sepsis.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Viral exploitation and subversion of the immune system through chemokine mimicry

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The viral CC chemokine-binding protein vCCI inhibits monocyte chemoattractant protein-1 activity by masking its CCR2B-binding site

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ gut intraepithelial lymphocytes

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

A role for CCR9 in T lymphocyte development and migration.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Mice lacking the murine interleukin-8 receptor homologue demonstrate paradoxical responses to acute and chronic experimental infection with Listeria monocytogenes.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Beneficial effects of targeting CCR5 in allograft recipients

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO( ) T cells.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Drug efficacy at G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

C-terminal cyclization of an SDF-1 small peptide analogue dramatically increases receptor affinity and activation of the CXCR4 receptor

1 reference

https://api.crossref.org/works/10.1016/S1367-5931(02)00351-4

7 January 2021

10.1016/S1367-5931(02)00351-4

Identifiers

DOI

1 reference

4 August 2017

1 reference