Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. (Q34750222)

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24 January 2020

title

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets (English)

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1

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Adele Murrell

12

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Charlotte Ling

13

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Miguel Constancia

14

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Susan E Ozanne

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author name string

Noel H Smith

2

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Marloes Dekker Nitert

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Matthew Ackers-Johnson

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Santiago Uribe-Lewis

5

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Yoko Ito

6

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R Huw Jones

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Victor E Marquez

8

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William Cairns

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Mohammed Tadayyon

10

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Laura P O'Neill

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language of work or name

English

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publication date

8 March 2011

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Proceedings of the National Academy of Sciences of the United States of America

24 January 2020

published in

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volume

108

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24 January 2020

issue

13

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24 January 2020

page(s)

5449-5454

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Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease

24 January 2020

cites work

1 reference

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Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.

7 July 2018

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7 July 2018

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Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies

7 July 2018

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Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.

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Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring

7 July 2018

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7 July 2018

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The complex language of chromatin regulation during transcription

7 July 2018

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7 July 2018

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

7 July 2018

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Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha

7 July 2018

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7 July 2018

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Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

7 July 2018

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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

7 July 2018

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Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression

7 July 2018

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

7 July 2018

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The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

26 October 2018

1 reference

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Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21388635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21388635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1019007108

1 reference

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24 January 2020

0 references

1 reference

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24 January 2020

PubMed publication ID

21388635

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388635 AND SRC:MED&resulttype=core&format=json