Telomere maintenance as a target for anticancer drug discovery (Q34743340)

4 August 2017

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title

Telomere maintenance as a target for anticancer drug discovery (English)

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4 August 2017

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Stephen Neidle

1

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4 August 2017

Gary Parkinson

series ordinal

2

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4 August 2017

publication date

1 May 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

5

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4 August 2017

page(s)

383-393

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4 August 2017

cites work

RHO-GTPases and cancer

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Four-dimensional control of the cell cycle

21 January 2018

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Switching and signaling at the telomere

21 January 2018

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The terminal DNA structure of mammalian chromosomes

21 January 2018

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Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang

21 January 2018

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Normal human chromosomes have long G-rich telomeric overhangs at one end

21 January 2018

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TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

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Pot1, the putative telomere end-binding protein in fission yeast and humans

21 January 2018

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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

21 January 2018

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G-quadruplex DNA structures--variations on a theme

21 January 2018

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G-Quadruplex DNA as a target for drug design

21 January 2018

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Control of telomere length by the human telomeric protein TRF1

21 January 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

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Telomerase and cancer: time to move from a promising target to a clinical reality.

21 January 2018

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Telomerase and the maintenance of chromosome ends

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The RNA component of human telomerase

21 January 2018

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Secondary structure of vertebrate telomerase RNA

21 January 2018

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hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

21 January 2018

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

21 January 2018

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TIN2, a new regulator of telomere length in human cells

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Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

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Ku acts in a unique way at the mammalian telomere to prevent end joining

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Direct activation of TERT transcription by c-MYC.

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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c-myc Suppression in Burkitt's lymphoma cells

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Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule

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Creation of human tumour cells with defined genetic elements

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Inhibition of telomerase limits the growth of human cancer cells.

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Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells

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Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

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Telomere maintenance by recombination in human cells.

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Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

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Identification of Determinants for Inhibitor Binding within the RNA Active Site of Human Telomerase Using PNA Scanning

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Inhibition of human telomerase by 2'-O-methyl-RNA

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Inhibition of telomerase by 2'-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells

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Inhibition of telomerase by G-quartet DNA structures

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G-quadruplex DNA: a potential target for anti-cancer drug design

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Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

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Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

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Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

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Telomere fusions caused by mutating the terminal region of telomeric DNA

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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase

21 January 2018

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Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex

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NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

21 January 2018

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Perylene diimide G-quadruplex DNA binding selectivity is mediated by ligand aggregation

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Cleavage of telomeric G-quadruplex DNA with perylene-EDTA*Fe(II).

21 January 2018

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Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye.

21 January 2018

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G-quadruplex DNA binding by a series of carbocyanine dyes

21 January 2018

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Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

21 January 2018

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Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

21 January 2018

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Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

21 January 2018

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2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase

21 January 2018

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Structural characterization of a guanine-quadruplex ligand complex

21 January 2018

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Telomere maintenance mechanisms as a target for drug development

21 January 2018

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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

21 January 2018

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The Bloom's syndrome helicase unwinds G4 DNA

31 March 2020

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Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

31 March 2020

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G-quadruplex DNA: a target for drug design

31 March 2020

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A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

31 March 2020

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Interaction of the dye ethidium bromide with DNA containing guanine repeats

31 March 2020

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Inhibition of human telomerase by a G-quadruplex-interactive compound

31 March 2020

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Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

31 March 2020

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Human telomerase inhibition by substituted acridine derivatives

31 March 2020

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Accelerated assembly of G-quadruplex structures by a small molecule

31 March 2020

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Telomerase assay using biotinylated-primer extension and magnetic separation of the products

31 March 2020

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Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones

31 March 2020

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Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

31 March 2020

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Selective interactions of cationic porphyrins with G-quadruplex structures

31 March 2020

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Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD793

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4 August 2017

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