New therapeutics that modulate chemokine networks (Q34743328)

4 August 2017

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title

New therapeutics that modulate chemokine networks (English)

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4 August 2017

Matthias K Schwarz

1

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4 August 2017

Timothy N C Wells

series ordinal

2

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4 August 2017

publication date

1 May 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

5

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4 August 2017

page(s)

347-358

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Structure and Functional Expression of a Human Interleukin-8 Receptor

4 August 2017

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The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3

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Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration

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Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1

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A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection

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Interfering with chemokine networks--the hope for new therapeutics

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Recent developments in modulating chemokine networks

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Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor

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Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.

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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

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Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection

21 January 2018

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

21 January 2018

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21 January 2018

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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

21 January 2018

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes

21 January 2018

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

21 January 2018

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Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection

21 January 2018

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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

21 January 2018

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

21 January 2018

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity

21 January 2018

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Combinatorial synthesis of CCR5 antagonists

21 January 2018

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

21 January 2018

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Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

21 January 2018

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Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication

21 January 2018

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Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

21 January 2018

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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

21 January 2018

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AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

21 January 2018

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Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4

21 January 2018

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

21 January 2018

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AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

21 January 2018

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Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

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An interleukin 5 mutant distinguishes between two functional responses in human eosinophils.

21 January 2018

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Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues

21 January 2018

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RANTES and MCP-3 antagonists bind multiple chemokine receptors

21 January 2018

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An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model

21 January 2018

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Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

21 January 2018

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Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

21 January 2018

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CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4( ) T cells: role of signal transduction

21 January 2018

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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

21 January 2018

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Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses

21 January 2018

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Nicotinamide N-oxides as CXCR2 antagonists

31 March 2020

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Selective lymphocyte chemokine receptor expression in the rheumatoid joint

31 March 2020

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Identification of a potent and nonpeptidyl ccr3 antagonist

31 March 2020

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HIV-1 entry inhibitors: evading the issue

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD795

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release_ob2qqaed2ndfrlba6bw2ylc3ry

4 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ob2qqaed2ndfrlba6bw2ylc3ry

mapped directly with Wikidata item

24 November 2022

based on heuristic

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