Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. (Q34743269)

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8 February 2020

title

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease (English)

1 reference

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transcriptional dysregulation

8 February 2020

main subject

Huntington's disease

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Sama F Sleiman

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Bo Li

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Bo Li

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Anatoly Starkov

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Rajnish Kumar Chaturvedi

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Daniel H Geschwind

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Stephen J McConoughey

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Stephen J McConoughey

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publication date

1 September 2010

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8 February 2020

published in

EMBO Molecular Medicine

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volume

2

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issue

9

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8 February 2020

page(s)

349-370

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describes a project that uses

8 February 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3068019

inferred from PubMed Central ID database lookup

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Regional mitochondrial respiratory activity in Huntington's disease brain

7 July 2018

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Labeling of epsilon-lysine crosslinking sites in proteins with peptide substrates of factor XIIIa and transglutaminase

7 July 2018

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The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases

7 July 2018

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Huntington's disease: tagged for clearance

7 July 2018

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In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

26 October 2018

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Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.

26 October 2018

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Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

26 October 2018

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

26 October 2018

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Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease

26 October 2018

1 reference

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Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

26 October 2018

1 reference

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HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

26 October 2018

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The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase

26 October 2018

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Mechanism for the inhibition of transglutaminase 2 by cystamine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Use of within-array replicate spots for assessing differential expression in microarray experiments

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Insoluble TATA-binding protein accumulation in Huntington's disease cortex.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Therapeutic effects of cystamine in a murine model of Huntington's disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Conformational changes in the nucleosome followed by the selective accessibility of histone glutamines in the transglutaminase reaction: effects of ionic strength

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Impaired mitochondrial function results in increased tissue transglutaminase activity in situ

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Core histones are glutaminyl substrates for tissue transglutaminase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3068019

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions

26 October 2018

1 reference

12 December 2020

1 reference

12 December 2020

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1 reference

12 December 2020

Use of the transglutaminase reaction to study the dissociation of histone N-terminal tails from DNA in nucleosome core particles

1 reference

12 December 2020

Distinct nuclear localization and activity of tissue transglutaminase

1 reference

12 December 2020

Identifiers

DOI

10.1002/EMMM.201000084

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20665636 AND SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20665636 AND SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

20665636

1 reference