High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. (Q34742691)

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English	High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.	scientific article

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1 March 2020

High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes (English)

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1 March 2020

human embryonic stem cell

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Laetitia Francelle

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Cécile Martinat

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Emmanuel Brouillet

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Benjamin Brinon

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Jérémie Charbord

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Maxime Feyeux

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Fabrice Casagrande

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Gwenaelle Aurégan

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Martine Guillermier

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Pedro Viegas

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Marc Lechuga

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1 September 2013

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1 March 2020

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Transcriptional activation of REST by Sp1 in Huntington's disease models

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST regulates distinct transcriptional networks in embryonic and neural stem cells

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Chromatin crosstalk in development and disease: lessons from REST

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST maintains self-renewal and pluripotency of embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

The establishment of neuronal properties is controlled by Sox4 and Sox11

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

The many faces of REST oversee epigenetic programming of neuronal genes

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST and CoREST modulate neuronal subtype specification, maturation and maintenance

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Disease-specific induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Brain mitochondrial defects amplify intracellular [Ca2 ] rise and neurodegeneration but not Ca2 entry during NMDA receptor activation.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

A genetic screen for candidate tumor suppressors identifies REST

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Brain-derived neurotrophic factor in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Brain-derived neurotrophic factor in Huntington disease

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Role of brain-derived neurotrophic factor in Huntington's disease

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

A microRNA-based gene dysregulation pathway in Huntington's disease

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Animal models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions.

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation

1 reference

https://api.crossref.org/works/10.1002/STEM.1430

21 January 2018

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