SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells (Q34732289)

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25 February 2020

title

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells (English)

1 reference

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25 February 2020

0 references

1

1 reference

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25 February 2020

7

Guy Sauvageau

1 reference

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25 February 2020

11

Trang Hoang

1 reference

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25 February 2020

5

Sabine Herblot

1 reference

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25 February 2020

author name string

Cedric S Tremblay

2

1 reference

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25 February 2020

Mathieu Tremblay

3

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25 February 2020

Shanti Rojas-Sutterlin

4

1 reference

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25 February 2020

Josée Hébert

6

1 reference

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25 February 2020

Sébastien Lemieux

8

1 reference

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25 February 2020

Eric Lécuyer

9

1 reference

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25 February 2020

Diogo F T Veiga

10

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25 February 2020

publication date

18 December 2014

1 reference

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25 February 2020

1 reference

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25 February 2020

volume

10

1 reference

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25 February 2020

issue

12

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25 February 2020

page(s)

e1004768

1 reference

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Creative Commons Attribution 4.0 International

25 February 2020

copyright license

start time

18 December 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

affy

object named as

Affy package

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice

7 July 2018

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Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

7 July 2018

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Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.

7 July 2018

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Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells

7 July 2018

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Thymus-autonomous T cell development in the absence of progenitor import

7 July 2018

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The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors

7 July 2018

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7 July 2018

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Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity

7 July 2018

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7 July 2018

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7 July 2018

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Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia.

7 July 2018

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7 July 2018

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NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

7 July 2018

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7 July 2018

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7 July 2018

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Promotion of direct reprogramming by transformation-deficient Myc.

7 July 2018

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Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

7 July 2018

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Functions of notch signaling in the immune system: consensus and controversies

7 July 2018

1 reference

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The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal

7 July 2018

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Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

A functional screen to identify novel effectors of hematopoietic stem cell activity

7 July 2018

1 reference

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7 July 2018

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E and ID proteins branch out.

7 July 2018

1 reference

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Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

7 July 2018

1 reference

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Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype.

7 July 2018

1 reference

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Molecular pathogenesis of T-cell leukaemia and lymphoma

7 July 2018

1 reference

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Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Notch signaling in leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

7 July 2018

1 reference

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

7 July 2018

1 reference

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From stem cell to T cell: one route or many?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Helix-loop-helix proteins and lymphocyte development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Activating Notch1 mutations in mouse models of T-ALL.

7 July 2018

1 reference

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments

7 July 2018

1 reference

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Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

affy--analysis of Affymetrix GeneChip data at the probe level

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

SCL: from the origin of hematopoiesis to stem cells and leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Gradient of E2A activity in B-cell development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

High Incidence of T-Cell Tumors in E2A-Null Mice and E2A/Id1 Double-Knockout Mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Positive and negative transcriptional control by the TAL1 helix-loop-helix protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia

7 July 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1( )c-Kit(-) cell generation through p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1004768

scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4270438

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

26 October 2018

1 reference

12 December 2020

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

1 reference

12 December 2020

Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation

1 reference

12 December 2020

T cell stimulation and expansion using anti-CD3/CD28 beads

1 reference

12 December 2020

Lineage infidelity in acute leukemia

1 reference

12 December 2020

Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1 reference

12 December 2020

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

1 reference

12 December 2020

Cancer stem cells: an evolving concept

1 reference

12 December 2020

Expansion of hematopoietic stem cells in the developing liver of a mouse embryo

1 reference

12 December 2020

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1004768

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522233 AND SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522233 AND SRC:MED&resulttype=core&format=json

25 February 2020

PubMed publication ID

25522233

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522233 AND SRC:MED&resulttype=core&format=json