A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex (Q34728646)

4 August 2017

title

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex (English)

1 reference

4 August 2017

Aude Dupré

1

1 reference

4 August 2017

Louise Boyer-Chatenet

2

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4 August 2017

Rose M Sattler

3

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4 August 2017

Ami P Modi

4

1 reference

4 August 2017

Ji-Hoon Lee

5

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4 August 2017

Matthew L Nicolette

6

1 reference

4 August 2017

Levy Kopelovich

7

1 reference

4 August 2017

Maria Jasin

8

1 reference

4 August 2017

Richard Baer

9

1 reference

4 August 2017

Tanya T Paull

10

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4 August 2017

Jean Gautier

11

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4 August 2017

publication date

6 January 2008

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4 August 2017

published in

Nature Chemical Biology

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4 August 2017

volume

4

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4 August 2017

issue

2

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4 August 2017

page(s)

119-125

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Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Involvement of novel autophosphorylation sites in ATM activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

ATM signaling and genomic stability in response to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Cell-cycle checkpoints and cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Identification of a novel protein regulating microtubule stability through a chemical approach

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Structural and functional analysis of Mre11-3.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

The Mre11 complex is required for ATM activation and the G2/M checkpoint

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Requirement of the MRN complex for ATM activation by DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

The DNA damage response: putting checkpoints in perspective

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

ATM-dependent phosphorylation of nibrin in response to radiation exposure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065498

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

7 July 2018

1 reference

The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

21 January 2018

1 reference

Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage

21 January 2018

1 reference

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.

21 January 2018

1 reference

The many interfaces of Mre11

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18176557

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18176557

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.63

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference

4 August 2017

1 reference