ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. (Q34728044)

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1 March 2020

title

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase (English)

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1 March 2020

0 references

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1

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1 March 2020

Ye Tian

2

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1 March 2020

author name string

Haixin Yuan

3

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1 March 2020

Hyun Woo Park

4

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1 March 2020

Yu-Yun Chang

5

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1 March 2020

Joungmok Kim

6

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1 March 2020

Haerin Kim

7

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1 March 2020

Thomas P Neufeld

8

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1 March 2020

Andrew Dillin

9

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1 March 2020

Kun-Liang Guan

10

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publication date

19 May 2013

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1 March 2020

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1 March 2020

volume

15

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issue

7

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1 March 2020

page(s)

741-750

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Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy

1 March 2020

cites work

1 reference

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Autophagy: renovation of cells and tissues

7 July 2018

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Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).

7 July 2018

1 reference

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The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy

7 July 2018

1 reference

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

7 July 2018

1 reference

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

7 July 2018

1 reference

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The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

7 July 2018

1 reference

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Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

7 July 2018

1 reference

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Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

7 July 2018

1 reference

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C. elegans screen identifies autophagy genes specific to multicellular organisms

7 July 2018

1 reference

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

7 July 2018

1 reference

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

7 July 2018

1 reference

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

7 July 2018

1 reference

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

7 July 2018

1 reference

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Amino acids activate mTOR complex 1 via Ca2 /CaM signaling to hVps34.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

The regulation and function of Class III PI3Ks: novel roles for Vps34.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

7 July 2018

1 reference

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Hierarchy of Atg proteins in pre-autophagosomal structure organization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

7 July 2018

1 reference

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

7 July 2018

1 reference

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

7 July 2018

1 reference

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hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

7 July 2018

1 reference

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Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

7 July 2018

1 reference

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

7 July 2018

1 reference

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Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains

7 July 2018

1 reference

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A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Selective autophagic degradation of maternally-loaded germline P granule components in somatic cells during C. elegans embryogenesis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885611

9 December 2018

Identifiers

DOI

10.1038/NCB2757

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Dimensions Publication ID

1 March 2020

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1 reference

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1 March 2020

PubMed publication ID

23685627

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23685627 AND SRC:MED&resulttype=core&format=json