Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. (Q34727801)

4 August 2017

title

Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. (English)

1 reference

4 August 2017

Bunsyo Shiotani

1

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4 August 2017

Hai Dang Nguyen

2

1 reference

4 August 2017

Pelle Håkansson

3

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4 August 2017

Alexandre Maréchal

4

1 reference

4 August 2017

Alice Tse

5

1 reference

4 August 2017

Hidetoshi Tahara

6

1 reference

4 August 2017

Lee Zou

7

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4 August 2017

publication date

16 May 2013

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4 August 2017

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4 August 2017

volume

3

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4 August 2017

issue

5

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4 August 2017

page(s)

1651-1662

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The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

4 August 2017

cites work

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Activation of DSB processing requires phosphorylation of CtIP by ATR.

7 July 2018

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Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

7 July 2018

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7 July 2018

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The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner

7 July 2018

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7 July 2018

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DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange

7 July 2018

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A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

7 July 2018

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7 July 2018

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7 July 2018

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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

7 July 2018

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MDC1 collaborates with TopBP1 in DNA replication checkpoint control

7 July 2018

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7 July 2018

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The DNA Damage Response: Making It Safe to Play with Knives

7 July 2018

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ATR: a master conductor of cellular responses to DNA replication stress

7 July 2018

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Continued primer synthesis at stalled replication forks contributes to checkpoint activation.

7 July 2018

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The role of RPA2 phosphorylation in homologous recombination in response to replication arrest

7 July 2018

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Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks

7 July 2018

1 reference

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The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms

7 July 2018

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Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

7 July 2018

1 reference

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

7 July 2018

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Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.

7 July 2018

1 reference

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TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.

7 July 2018

1 reference

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Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

7 July 2018

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The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

7 July 2018

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ATR: an essential regulator of genome integrity

7 July 2018

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

7 July 2018

1 reference

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NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

7 July 2018

1 reference

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Human CtIP promotes DNA end resection

7 July 2018

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Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair

7 July 2018

1 reference

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The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

7 July 2018

1 reference

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

7 July 2018

1 reference

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The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

The structural determinants of checkpoint activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

TopBP1 activates the ATR-ATRIP complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Nbs1 is required for ATR-dependent phosphorylation events

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Replication protein A-mediated recruitment and activation of Rad17 complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Requirement of the MRN complex for ATM activation by DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint

7 July 2018

1 reference

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

7 July 2018

1 reference

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Recombinant replication protein A: expression, complex formation, and functional characterization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Rad50 depletion impacts upon ATR-dependent DNA damage responses

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680100

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

26 October 2018

1 reference

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10.1016/J.CELREP.2013.04.018

26 October 2018

Identifiers

DOI

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4 August 2017

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4 August 2017

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