Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. (Q34712302)

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19 January 2020

title

Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex (English)

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19 January 2020

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2

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19 January 2020

author name string

Gongxiong Wu

1

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19 January 2020

Aliakbar Shahsafaei

3

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19 January 2020

Wenping Song

4

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19 January 2020

Martin Dobarro

5

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19 January 2020

Galina K Sukhova

6

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19 January 2020

Rod R Bronson

7

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19 January 2020

Guo-Ping Shi

8

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19 January 2020

Russell P Rother

9

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19 January 2020

Jose A Halperin

10

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19 January 2020

Xuebin Qin

11

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19 January 2020

publication date

8 January 2009

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19 January 2020

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19 January 2020

volume

104

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19 January 2020

issue

4

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19 January 2020

page(s)

550-558

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Generation and phenotyping of mCd59a and mCd59b double-knockout mice

19 January 2020

cites work

1 reference

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7 July 2018

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Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease

7 July 2018

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Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice

7 July 2018

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The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.

7 July 2018

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Assessment of unstable atherosclerosis in mice

7 July 2018

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Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development

7 July 2018

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Complement and complement regulatory proteins as potential molecular targets for vascular diseases

7 July 2018

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Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility

7 July 2018

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Critical review of acylation-stimulating protein physiology in humans and rodents

7 July 2018

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Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b

7 July 2018

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Molecular basis for a link between complement and the vascular complications of diabetes

7 July 2018

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Atherosclerosis — An Inflammatory Disease

7 July 2018

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Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells

7 July 2018

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Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells

7 July 2018

1 reference

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Regulation of complement membrane attack complex formation in myocardial infarction

7 July 2018

1 reference

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Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction

7 July 2018

1 reference

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Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59.

7 July 2018

1 reference

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Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.

26 October 2018

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C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1.

26 October 2018

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Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267695

Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction

26 October 2018

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Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q.

26 October 2018

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Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes

26 October 2018

1 reference

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CD59a is the primary regulator of membrane attack complex assembly in the mouse.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267695

Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice

26 October 2018

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Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy

26 October 2018

1 reference

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Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice

26 October 2018

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ApoE(-/-) mice develop atherosclerosis in the absence of complement component C5.

26 October 2018

1 reference

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High-level endothelial expression of human CD59 prolongs heart function in an ex vivo model of xenograft rejection

26 October 2018

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12 December 2020

Local activation of the complement system in endoneurial microvessels of diabetic neuropathy

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12 December 2020

IgG binding to cytoskeletal intermediate filaments activates the complement cascade

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12 December 2020

Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits

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12 December 2020

Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin

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12 December 2020

Complement-induced release of monocyte chemotactic protein-1 from human smooth muscle cells. A possible initiating event in atherosclerotic lesion formation

1 reference

12 December 2020

Localization of the terminal C5b-9 complement complex in the human aortic atherosclerotic wall

1 reference

12 December 2020

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

12 December 2020

Modified low density lipoproteins differentially bind and activate the C1 complex of complement

1 reference

12 December 2020

Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and phosphatidylinositol 3-kinase

1 reference

12 December 2020

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

1 reference

12 December 2020

Transient changes in erythrocyte membrane permeability are induced by sublytic amounts of the complement membrane attack complex (C5b-9)

1 reference

12 December 2020

Immunoelectron-microscopic localization of the terminal C5b-9 complement complex in human atherosclerotic fibrous plaque

1 reference

12 December 2020

Serum C-reactive protein and complement proteins in patients with acute myocardial infarction

1 reference

12 December 2020

10.1161/CIRCRESAHA.108.191361

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19131645 AND SRC:MED&resulttype=core&format=json

19 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19131645 AND SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

19131645

1 reference