The emerging genetic architecture of type 2 diabetes (Q34712198)

4 August 2017

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title

The emerging genetic architecture of type 2 diabetes (English)

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4 August 2017

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3

C Ronald Kahn

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4 August 2017

Alessandro Doria

1

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4 August 2017

Mary-Elizabeth Patti

series ordinal

2

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4 August 2017

publication date

1 September 2008

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4 August 2017

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4 August 2017

volume

8

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4 August 2017

issue

3

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4 August 2017

page(s)

186-200

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Diabetes risk begins in utero

4 August 2017

cites work

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The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects

7 July 2018

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7 July 2018

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Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations

7 July 2018

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Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

7 July 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

7 July 2018

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7 July 2018

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7 July 2018

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Variation in FTO contributes to childhood obesity and severe adult obesity

7 July 2018

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A common allele on chromosome 9 associated with coronary heart disease

7 July 2018

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A common variant on chromosome 9p21 affects the risk of myocardial infarction

7 July 2018

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

7 July 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

7 July 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

7 July 2018

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

7 July 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

7 July 2018

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Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

7 July 2018

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Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans

7 July 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

7 July 2018

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Human obesity and insulin resistance: lessons from experiments of nature.

7 July 2018

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In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

7 July 2018

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Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity

7 July 2018

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

7 July 2018

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Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis

7 July 2018

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Structural variation in the human genome

7 July 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

7 July 2018

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Zinc, the pancreas, and diabetes: insights from rodent studies and future directions

7 July 2018

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

7 July 2018

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Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

7 July 2018

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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

7 July 2018

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Genetics of type 2 diabetes mellitus: status and perspectives

7 July 2018

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Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex.

7 July 2018

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Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

7 July 2018

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TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

7 July 2018

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7 July 2018

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Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

7 July 2018

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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

7 July 2018

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Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

7 July 2018

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

7 July 2018

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective

7 July 2018

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Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha

7 July 2018

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On the allelic spectrum of human disease

7 July 2018

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7 July 2018

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Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

7 July 2018

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Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

7 July 2018

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

7 July 2018

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

7 July 2018

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Wnt signaling and the activation of myogenesis in mammals.

7 July 2018

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A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance

7 July 2018

1 reference

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

7 July 2018

1 reference

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cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein

7 July 2018

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Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance--a population-based twin study.

7 July 2018

1 reference

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A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

7 July 2018

1 reference

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

7 July 2018

1 reference

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A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

7 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

7 July 2018

1 reference

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Genetics of non-insulin-dependent (type-II) diabetes mellitus

7 July 2018

1 reference

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Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers

7 July 2018

1 reference

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A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

7 July 2018

1 reference

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A cell cycle regulator potentially involved in genesis of many tumor types

7 July 2018

1 reference

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Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

7 July 2018

1 reference

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Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis

7 July 2018

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Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide

7 July 2018

1 reference

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The influence of zinc supplementation on glucose homeostasis in NIDDM.

7 July 2018

1 reference

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Mapping genes in diabetes. Genetic epidemiological perspective

7 July 2018

1 reference

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Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

7 July 2018

1 reference

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Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

26 October 2018

1 reference

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Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study

26 October 2018

1 reference

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Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus

26 October 2018

1 reference

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Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

26 October 2018

1 reference

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A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets

26 October 2018

1 reference

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Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies

26 October 2018

1 reference

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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

26 October 2018

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Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Economic costs of diabetes in the US in 2002.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K( ) channels

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Dietary zinc supplementation attenuates hyperglycemia in db/db mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Regulation of a transcription factor network required for differentiation and metabolism

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4267677

Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes

9 December 2018

1 reference

12 December 2020

Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight

1 reference

12 December 2020

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

12 December 2020

A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array

1 reference

12 December 2020

Prevalence of diabetes in Mexican Americans, Cubans, and Puerto Ricans from the Hispanic Health and Nutrition Examination Survey, 1982-1984

1 reference

12 December 2020

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations

1 reference

12 December 2020

Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key

1 reference

12 December 2020

Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development

1 reference

12 December 2020

Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies

1 reference

12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

12 December 2020

Orchestration of glucose homeostasis: from a small acorn to the California oak

1 reference

12 December 2020

10.1016/J.CMET.2008.08.006

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference