Hedgehog regulates smoothened activity by inducing a conformational switch (Q34706637)

4 August 2017

title

Hedgehog regulates smoothened activity by inducing a conformational switch (English)

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4 August 2017

main subject

Smoothened Dmel_CG11561

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GOA release 2020-03-11

Hedgehog Dmel_CG4637

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GOA release 2020-03-11

Frizzled 2 Dmel_CG9739

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GOA release 2020-03-11

2

Chao Tong

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4 August 2017

Yun Zhao

1

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4 August 2017

Jin Jiang

series ordinal

3

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4 August 2017

language of work or name

English

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publication date

24 October 2007

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4 August 2017

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4 August 2017

volume

450

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4 August 2017

issue

7167

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4 August 2017

page(s)

252-258

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Hedgehog signaling in animal development: paradigms and principles

4 August 2017

cites work

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7 January 2021

Drosophila hedgehog acts as a morphogen in cellular patterning.

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7 January 2021

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

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7 January 2021

Sonic hedgehog mediates the polarizing activity of the ZPA

1 reference

7 January 2021

Decoding the Hedgehog signal in animal development.

1 reference

7 January 2021

Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein

1 reference

7 January 2021

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

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7 January 2021

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

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7 January 2021

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

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7 January 2021

Dual roles for patched in sequestering and transducing Hedgehog

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7 January 2021

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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7 January 2021

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

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7 January 2021

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

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7 January 2021

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

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7 January 2021

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

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7 January 2021

Cell signaling by receptor tyrosine kinases

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7 January 2021

How receptors talk to trimeric G proteins

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7 January 2021

Fluorescence resonance energy transfer imaging microscopy

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7 January 2021

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

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7 January 2021

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

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7 January 2021

Eph signaling: a structural view

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7 January 2021

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

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7 January 2021

Vertebrate Smoothened functions at the primary cilium

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7 January 2021

Patched1 regulates hedgehog signaling at the primary cilium

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7 January 2021

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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7 January 2021

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

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7 January 2021

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

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7 January 2021

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

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7 January 2021

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

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7 January 2021

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

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7 January 2021

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

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7 January 2021

Protein kinase A and hedgehog signaling in Drosophila limb development

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7 January 2021

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

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7 January 2021

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

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7 January 2021

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development

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7 January 2021

Identifiers

DOI

10.1038/NATURE06225

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Dimensions Publication ID

4 August 2017

1045177487

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Fatcat ID

release_q5ujfcdnlfboziixtifyrc5wey

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Fatcat

https://api.fatcat.wiki/v0/release/q5ujfcdnlfboziixtifyrc5wey

24 November 2022

mapped directly with Wikidata item

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