The Gli code: an information nexus regulating cell fate, stemness and cancer. (Q34685494)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

review article

1 reference

title

The Gli code: an information nexus regulating cell fate, stemness and cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

Barbara Stecca

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Ariel Ruiz i Altaba

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

publication date

12 September 2007

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

published in

Trends in Cell Biology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

volume

17

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

issue

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

438-447

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

Patched1 regulates hedgehog signaling at the primary cilium

7 January 2020

cites work

1 reference

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Essential role of stromally induced hedgehog signaling in B-cell malignancies

7 July 2018

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

7 July 2018

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Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

7 July 2018

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

7 July 2018

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

7 July 2018

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Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

7 July 2018

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Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

7 July 2018

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Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.

7 July 2018

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Identification of pancreatic cancer stem cells

7 July 2018

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A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome

7 July 2018

1 reference

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

7 July 2018

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Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer

7 July 2018

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Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects

7 July 2018

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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

7 July 2018

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Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

7 July 2018

1 reference

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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

7 July 2018

1 reference

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The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling

7 July 2018

1 reference

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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

7 July 2018

1 reference

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

7 July 2018

1 reference

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Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling

7 July 2018

1 reference

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Dual degradation signals control Gli protein stability and tumor formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Complementary Gli activity mediates early patterning of the mouse visual system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Prospective identification of tumorigenic prostate cancer stem cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

A tumorigenic subpopulation with stem cell properties in melanomas

7 July 2018

1 reference

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In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

7 July 2018

1 reference

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Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation

7 July 2018

1 reference

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Neural stem cells and the origin of gliomas

7 July 2018

1 reference

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Cooperative requirement of the Gli proteins in neurogenesis

7 July 2018

1 reference

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A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

7 July 2018

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

7 July 2018

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Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling

7 July 2018

1 reference

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

7 July 2018

1 reference

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Unexpected Hedgehog-Wnt interactions in epithelial differentiation

7 July 2018

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Identification of human brain tumour initiating cells

7 July 2018

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MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription

7 July 2018

1 reference

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Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

7 July 2018

1 reference

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

7 July 2018

1 reference

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Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching

7 July 2018

1 reference

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

7 July 2018

1 reference

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REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

7 July 2018

1 reference

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

The emergent design of the neural tube: prepattern, SHH morphogen and GLI code

7 July 2018

1 reference

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

7 July 2018

1 reference

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

7 July 2018

1 reference

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

7 July 2018

1 reference

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

7 July 2018

1 reference

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Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Small molecule modulation of Smoothened activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

7 July 2018

1 reference

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Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Physical and functional interactions between Zic and Gli proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Gli2 functions in FGF signaling during antero-posterior patterning

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

7 July 2018

1 reference

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Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

7 July 2018

1 reference

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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Gli proteins encode context-dependent positive and negative functions: implications for development and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Sonic hedgehog regulates the growth and patterning of the cerebellum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Catching a Gli-mpse of Hedgehog

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

A search for gli expression in tumors of the central nervous system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Identification of an amplified, highly expressed gene in a human glioma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

A negative feedback signaling network underlies oncogene-induced senescence

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1( /-)p53(-/-) mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Medulloblastoma growth inhibition by hedgehog pathway blockade

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Wnt signals are targets and mediators of Gli function.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Gli/Zic factors pattern the neural plate by defining domains of cell differentiation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601665

Teratogenic compounds ofVeratrum californicum (Durand). X. Cyclopia in rabbits produced by cyclopamine

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17845852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17845852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Carboxy-terminally truncated Gli3 proteins associate with Smads

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17845852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TCB.2007.06.007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17845852 AND SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

17845852

1 reference