Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. (Q34683782)

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21 January 2020

title

Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program (English)

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21 January 2020

2

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21 January 2020

Richard B Lock

3

1 reference

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21 January 2020

C P Reynolds

7

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21 January 2020

Min H Kang

8

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21 January 2020

12

Peter J Houghton

1 reference

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21 January 2020

9

John M Maris

1 reference

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21 January 2020

11

Malcolm A Smith

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21 January 2020

1

E Anders Kolb

1 reference

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21 January 2020

6

Stephen T Keir

1 reference

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21 January 2020

4

Hernan Carol

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21 January 2020

10

Catherine Billups

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21 January 2020

author name string

Christopher L Morton

5

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21 January 2020

publication date

22 December 2010

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21 January 2020

published in

Pediatric Blood & Cancer

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21 January 2020

volume

56

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21 January 2020

issue

4

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21 January 2020

page(s)

595-603

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Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program.

21 January 2020

cites work

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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.

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Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development

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7 July 2018

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Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

7 July 2018

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Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.

7 July 2018

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A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

7 July 2018

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Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

7 July 2018

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IGF-I mediated survival pathways in normal and malignant cells

7 July 2018

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

7 July 2018

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IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma

7 July 2018

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Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

7 July 2018

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The role of the IGF axis in hepatocarcinogenesis

7 July 2018

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Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas

7 July 2018

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Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

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Insulin-like growth factor (IGF) I down-regulates type 1 IGF receptor (IGF 1R) and reduces the IGF I response in A549 non-small-cell lung cancer and Saos-2/B-10 osteoblastic osteosarcoma cells.

7 July 2018

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7 July 2018

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7 July 2018

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The pediatric preclinical testing program: description of models and early testing results.

28 July 2018

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Crossref

https://api.crossref.org/works/10.1002/PBC.22741

Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor.

21 January 2018

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Crossref

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Insulin-like growth factor I receptor activity in human medulloblastomas.

21 January 2018

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Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice

26 October 2018

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The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models

26 October 2018

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12 December 2020

The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma

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12 December 2020

Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells

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12 December 2020

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target

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12 December 2020

High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma

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12 December 2020

Identifiers

DOI

10.1002/PBC.22741

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21298745 AND SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21298745 AND SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

21298745

1 reference