Gli and hedgehog in cancer: tumours, embryos and stem cells. (Q34665999)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12044012 AND SRC:MED&resulttype=core&format=json

9 November 2019

review article

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title

Gli and hedgehog in cancer: tumours, embryos and stem cells (English)

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9 November 2019

2

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9 November 2019

author name string

Ariel Ruiz i Altaba

series ordinal

1

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9 November 2019

Nadia Dahmane

series ordinal

3

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9 November 2019

language of work or name

English

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publication date

1 May 2002

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9 November 2019

published in

Nature Reviews Cancer

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9 November 2019

volume

2

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9 November 2019

issue

5

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9 November 2019

page(s)

361-372

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Gli proteins and Hedgehog signaling: development and cancer

9 November 2019

cites work

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

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Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

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Basal cell carcinomas in mice overexpressing sonic hedgehog

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Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

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Basal cell carcinomas in mice overexpressing Gli2 in skin

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The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

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Activating Smoothened mutations in sporadic basal-cell carcinoma

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Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin

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Activation of expression of hedgehog target genes in basal cell carcinomas

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Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome

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Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling

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Sonic hedgehog signaling is essential for hair development

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Essential role for Sonic hedgehog during hair follicle morphogenesis

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Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

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Involvement of follicular stem cells in forming not only the follicle but also the epidermis

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At the roots of a never-ending cycle.

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Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro

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Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.

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Prediction of central nervous system embryonal tumour outcome based on gene expression

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Gliomagenesis: genetic alterations and mouse models

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Malignant glioma: genetics and biology of a grave matter.

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

31 March 2020

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Identification of an amplified, highly expressed gene in a human glioma

31 March 2020

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In situ hybridization with single-stranded RNA probes to demonstrate infrequently elevated gli mRNA and no increased ras mRNA levels in meningiomas and astrocytomas

31 March 2020

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A search for gli expression in tumors of the central nervous system

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Teratogen-mediated inhibition of target tissue response to Shh signaling

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development

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Immunolocalization of sonic hedgehog (Shh) in developing mouse lung

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Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium

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Molecular genetics of prostate cancer.

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Involvement of PTCH gene in various noninflammatory cysts

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Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice

31 March 2020

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Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

31 March 2020

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Hedgehog signaling in mouse mammary gland development and neoplasia

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The Hallmarks of Cancer

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Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

31 March 2020

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The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A

31 March 2020

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Identification of sonic hedgehog-responsive genes using cDNA microarray

31 March 2020

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Epigenetic gene deregulation in cancer.

31 March 2020

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Stem cells, cancer, and cancer stem cells

31 March 2020

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 March 2020

1 reference

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

31 March 2020

1 reference

Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling

31 March 2020

1 reference

Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells.

31 March 2020

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Genetic profile of gliosarcomas

31 March 2020

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

31 March 2020

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Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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A unified hypothesis on the lineage of neural stem cells

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Amphibian limb regeneration: rebuilding a complex structure

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Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization, and clonal analysis

31 March 2020

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Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

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Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

31 March 2020

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A role of PDGFRalpha in basal cell carcinoma proliferation

31 March 2020

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Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

31 March 2020

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Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.

31 March 2020

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The IGF/IGFBP system in CNS malignancy

31 March 2020

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Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

31 March 2020

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Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

31 March 2020

1 reference

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

31 March 2020

1 reference

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

31 March 2020

1 reference

The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

31 March 2020

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

31 March 2020

1 reference

Radial glial identity is promoted by Notch1 signaling in the murine forebrain

31 March 2020

1 reference

Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation

31 March 2020

1 reference

The glial and mesenchymal elements of gliosarcomas share similar genetic alterations.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Teratocarcinomas and other neoplasms as developmental defects in gene expression.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC796

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12044012 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 November 2019

1004617577

0 references

1 reference