Kras as a key oncogene and therapeutic target in pancreatic cancer (Q34659332)

3 August 2017

title

Kras as a key oncogene and therapeutic target in pancreatic cancer (English)

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3 August 2017

1 reference

Meredith A Collins

1

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3 August 2017

Marina Pasca di Magliano

series ordinal

2

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3 August 2017

publication date

1 January 2013

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3 August 2017

published in

Frontiers in Physiology

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3 August 2017

volume

4

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3 August 2017

page(s)

407

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Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance

3 August 2017

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Metastatic pancreatic cancer is dependent on oncogenic Kras in mice

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7 July 2018

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7 July 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

7 July 2018

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Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer

7 July 2018

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An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.

7 July 2018

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The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras.

7 July 2018

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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

7 July 2018

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7 July 2018

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Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage

7 July 2018

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

7 July 2018

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RAS oncogenes: weaving a tumorigenic web

7 July 2018

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7 July 2018

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

7 July 2018

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Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

7 July 2018

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STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

7 July 2018

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Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

7 July 2018

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MEK1 mutations confer resistance to MEK and B-RAF inhibition

7 July 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

7 July 2018

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

7 July 2018

1 reference

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer.

7 July 2018

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

7 July 2018

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A paracrine requirement for hedgehog signalling in cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

MAP kinase signalling pathways in cancer

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Precursor lesions of pancreatic cancer: molecular pathology and clinical implications

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling

7 July 2018

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The use of targeted mouse models for preclinical testing of novel cancer therapeutics.

7 July 2018

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Development of farnesyl transferase inhibitors: a review

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Ras family signaling: therapeutic targeting

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Risk of pancreatic adenocarcinoma in chronic pancreatitis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Pancreatitis as a risk for pancreatic cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Mechanisms of signal transduction by Ras

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Increasing complexity of Ras signaling.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3896882

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

9 December 2018

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12 December 2020

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

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12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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12 December 2020

Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups

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12 December 2020

Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer

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12 December 2020

High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer

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12 December 2020

Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis

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12 December 2020

Identifiers

DOI

10.3389/FPHYS.2013.00407

1 reference

3 August 2017

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3 August 2017

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