Colorectal cancer stem cells and their implications for novel anticancer therapy (Q34656802)

3 August 2017

title

Colorectal cancer stem cells and their implications for novel anticancer therapy (English)

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3 August 2017

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neoplastic stem cells

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Daniel Klotz

1

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3 August 2017

publication date

1 April 2013

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Expert Review of Anticancer Therapy

3 August 2017

published in

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3 August 2017

volume

13

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3 August 2017

issue

4

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3 August 2017

page(s)

461-468

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Colorectal Cancer Stem Cells: Biology and Therapeutic Implications.

3 August 2017

cites work

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The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response

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Identifying the stem cell of the intestinal crypt: strategies and pitfalls

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Characterization of epithelial cell shedding from human small intestine.

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Intestinal stem cells

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Wnt signaling in the intestinal epithelium: from endoderm to cancer

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Explant culture of gastrointestinal tissue: a review of methods and applications

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Tissue-resident adult stem cell populations of rapidly self-renewing organs

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

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Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

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Crypt stem cells as the cells-of-origin of intestinal cancer

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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

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Cell regulation by the Apc protein Apc as master regulator of epithelia.

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APC and the three-hit hypothesis

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Identification of FAP locus genes from chromosome 5q21

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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A genetic model for colorectal tumorigenesis

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Lineage tracing reveals Lgr5 stem cell activity in mouse intestinal adenomas

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LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines

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Cerebral hemorrhage, warfarin, and intravenous tPA: the real risk is not treating

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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

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Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

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Trastuzumab--mechanism of action and use in clinical practice

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Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer

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Single-cell dissection of transcriptional heterogeneity in human colon tumors

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Wnt signaling, stem cells, and cancer of the gastrointestinal tract

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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

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The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

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Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

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Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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Heterogeneity in cancer: cancer stem cells versus clonal evolution

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Human tumour clonality assessment--flawed but necessary

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

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Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition

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The genomic landscapes of human breast and colorectal cancers

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A subpopulation of CD26 cancer stem cells with metastatic capacity in human colorectal cancer

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

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Mitosis is not a key target of microtubule agents in patient tumors.

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Cancer stem cells: impact, heterogeneity, and uncertainty

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Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

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Characterization of the Intestinal Cancer Stem Cell Marker CD166 in the Human and Mouse Gastrointestinal Tract

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Phenotypic characterization of human colorectal cancer stem cells

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Tumors as organs: complex tissues that interface with the entire organism

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Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

21 January 2018

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Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations

21 January 2018

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Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.

21 January 2018

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NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer

21 January 2018

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Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

21 January 2018

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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The basics of epithelial-mesenchymal transition

21 January 2018

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Interactions between cancer stem cells and their niche govern metastatic colonization

21 January 2018

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Tumor self-seeding by circulating cancer cells

21 January 2018

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Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

21 January 2018

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Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition

21 January 2018

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Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

21 January 2018

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A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis

21 January 2018

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The human microbiome project

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Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERA.13.17

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3 August 2017

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