Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport (Q34646307)

3 August 2017

title

Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport (English)

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3 August 2017

Becky M Bola

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Amy Chadwick

object named as

Amy L Chadwick

2

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Ian Stratford

object named as

Ian J Stratford

9

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Kaye Williams

6

object named as

Kaye J Williams

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3 August 2017

8

Susan E Critchlow

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3 August 2017

5

Brian A Telfer

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3 August 2017

Filippos Michopoulos

3

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3 August 2017

Kathryn G Blount

4

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3 August 2017

Paul D Smith

7

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3 August 2017

publication date

3 October 2014

1 reference

Molecular Cancer Therapeutics

3 August 2017

published in

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3 August 2017

volume

13

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3 August 2017

issue

12

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3 August 2017

page(s)

2805-2816

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Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.

3 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.

7 July 2018

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Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma.

26 October 2018

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The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer.

26 October 2018

1 reference

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Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258406

The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258406

Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle

26 October 2018

1 reference

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Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance

26 October 2018

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Lactate and pH in the brain: association and dissociation in different pathophysiological states

26 October 2018

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12 December 2020

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

1 reference

12 December 2020

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

1 reference

12 December 2020

Lactate, choline, and creatine levels measured by vitro 1H-MRS as prognostic parameters in patients with non-small-cell lung cancer

1 reference

12 December 2020

10.1158/1535-7163.MCT-13-1091

Identifiers

DOI

1 reference

3 August 2017

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3 August 2017

1 reference