Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation (Q34627083)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21285512 AND SRC:MED&resulttype=core&format=json

21 January 2020

title

Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation (English)

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21 January 2020

4

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21 January 2020

James A. Bankson

8

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21 January 2020

author name string

Yongxing Wang

1

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21 January 2020

Young-Ah Suh

2

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21 January 2020

Maren Y Fuller

3

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21 January 2020

Shunbin Xiong

5

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21 January 2020

Tamara Terzian

6

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21 January 2020

Alfonso Quintás-Cardama

7

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21 January 2020

Adel K El-Naggar

9

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21 January 2020

Guillermina Lozano

10

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21 January 2020

language of work or name

English

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publication date

1 March 2011

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Journal of Clinical Investigation

21 January 2020

published in

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21 January 2020

volume

121

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21 January 2020

issue

3

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21 January 2020

page(s)

893-904

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describes a project that uses

21 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Mdm2 and Mdm4 loss regulates distinct p53 activities

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

7 July 2018

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P53 promoter selection: choosing between life and death

7 July 2018

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

7 July 2018

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7 July 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 July 2018

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Restoration of p53 function leads to tumour regression in vivo

7 July 2018

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The oncogenic roles of p53 mutants in mouse models

7 July 2018

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Modeling the therapeutic efficacy of p53 restoration in tumors

7 July 2018

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Exploiting the p53 pathway for the diagnosis and therapy of human cancer.

7 July 2018

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Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells

7 July 2018

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7 July 2018

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Intrinsic tumour suppression

7 July 2018

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P53 is a tumor suppressor gene

7 July 2018

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7 July 2018

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Why did p53 gene therapy fail in ovarian cancer?

7 July 2018

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Cancer gene therapy: an awkward adolescence

7 July 2018

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Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

7 July 2018

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

7 July 2018

1 reference

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

7 July 2018

1 reference

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PUMA, a novel proapoptotic gene, is induced by p53

7 July 2018

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High metastatic potential in mice inheriting a targeted p53 missense mutation

7 July 2018

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Dosage-dependent dominance over wild-type p53 of a mutant p53 isolated from nasopharyngeal carcinoma.

7 July 2018

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Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines

7 July 2018

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How loops, beta sheets, and alpha helices help us to understand p53.

7 July 2018

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Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

7 July 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

7 July 2018

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Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation

7 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 July 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 July 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 July 2018

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Comparative binding of p53 to its promoter and DNA recognition elements

7 July 2018

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

26 October 2018

1 reference

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Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study

26 October 2018

1 reference

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A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

26 October 2018

1 reference

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An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

26 October 2018

1 reference

12 December 2020

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

12 December 2020

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies

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12 December 2020

Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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12 December 2020

Identifiers

DOI

10.1172/JCI44504

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21285512 AND SRC:MED&resulttype=core&format=json

release_fxoryutmbfc43bfqeurknar2p4

21 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fxoryutmbfc43bfqeurknar2p4

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21285512 AND SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

21285512

1 reference